Clinical Trials Updated in 2025

NCT05771428 | COMPLETED | PHASE2

263 participants

Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-552 Capsules Moves Through the Body of Participants Aged 50 to 90 Years With Mild Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-06-05
Completion:: 2024-08-06

Conditions

Alzheimer's Disease (AD)

Interventions

DRUG

Results Available

NCT05769062 | TERMINATED | NA

22 participants

Identification and Prevention of Pelvic Floor Dysfunction in Gynecologic Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-05-30
Completion:: 2025-10-10

Conditions

Gynecologic Cancer

Interventions

PROCEDURE

No Results Yet

NCT05722743 | COMPLETED | NA

84 participants

Person-Environment Fit for Persons With Dementia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-06-14
Completion:: 2025-06-20

Conditions

Dementia Alzheimers
Alzheimer Disease

Interventions

BEHAVIORAL

No Results Yet

NCT05715463 | ACTIVE_NOT_RECRUITING | NA

101 participants

Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-03-01
Completion:: 2025-10-14

Conditions

Rheumatoid Arthritis
Palindromic Arthritis
Juvenile Rheumatoid Arthritis
Ankylosing Spondylitis
Sacroiliitis
Psoriatic Arthritis
Mixed Connective Tissue Disease
Lupus
Enteropathic Arthropathies
Systemic Sclerosis
Sjogren's Syndrome
Sicca Syndrome
Inflammatory Arthritis
Undifferentiated Connective Tissue Diseases

Interventions

OTHER

No Results Yet

NCT05672199 | TERMINATED | PHASE2

25 participants

Long-term Safety and Efficacy of Efavaleukin Alfa in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-04-28
Completion:: 2024-10-31

Conditions

Ulcerative Colitis

Interventions

DRUG

No Results Yet

NCT05633017 | COMPLETED

52 participants

Breathing With a Facemask Exercise Performance

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-11-29
Completion:: 2023-12-17

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT05630547 | TERMINATED | PHASE2

174 participants

A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-12-19
Completion:: 2024-11-21

Conditions

Multiple Sclerosis

Interventions

DRUG
OTHER

Results Available

NCT05621317 | ACTIVE_NOT_RECRUITING | PHASE2

90 participants

A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-02-09
Completion:: 2025-11-30

Conditions

Peanut Allergy
Peanut Hypersensitivity
Peanut-Induced Anaphylaxis
Immune System Diseases

Interventions

BIOLOGICAL

No Results Yet

NCT05481411 | COMPLETED | PHASE1

25 participants

A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-09-13
Completion:: 2023-04-05

Conditions

Hepatic Impairment

Interventions

DRUG

No Results Yet

NCT05439772 | COMPLETED | PHASE4

41 participants

Examining the Effect of Ondansetron on Bowel Prep Success

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-01-01
Completion:: 2023-07-01

Conditions

Abdominal Pain
Inflammatory Bowel Diseases
Eosinophilic Gastroenteritis
Diarrhea
Hematochezia
Weight Loss

Interventions

DRUG

No Results Yet

NCT05381948 | COMPLETED | PHASE2

161 participants

Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-06-30
Completion:: 2023-11-29

Conditions

Wet Age-related Macular Degeneration

Interventions

DRUG

Results Available

NCT05371093 | ACTIVE_NOT_RECRUITING | PHASE3

231 participants

Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-09-22
Completion:: 2030-10-31

Conditions

Relapsed/Refractory Follicular Lymphoma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT05343715 | COMPLETED | PHASE1

24 participants

PK/PD Study of 2 Agalsidase Formulations in Single Dose of 1 mg/kg Administered to Healthy Volunteers as IV Infusion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-10-23
Completion:: 2022-03-06

Conditions

Fabry Disease

Interventions

BIOLOGICAL

Results Available

NCT05301751 | COMPLETED | PHASE2

25 participants

A Single Ascending Dose Cohort Study of AG-73305 in DME Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-05-19
Completion:: 2023-09-28

Conditions

Diabetic Macular Edema

Interventions

BIOLOGICAL

Results Available

NCT05215951 | TERMINATED | PHASE2

4 participants

Osimertinib Plus Chemotherapy in Uncommon EGFRm NSCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-01-19
Completion:: 2023-03-09

Conditions

Lung Cancer

Interventions

DRUG

Results Available

NCT05125952 | COMPLETED | NA

16 participants

Assessing Ventilator Safety in Patients on Pressure-Support Ventilation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-02-08
Completion:: 2023-11-21

Conditions

Acute Respiratory Failure
Mechanical Ventilation Complication
Ventilator-Induced Lung Injury

Interventions

DEVICE

Results Available

NCT05120726 | TERMINATED | PHASE4

5 participants

A Novel Therapeutic Treatment of Pyoderma Gangrenosum

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-06-02
Completion:: 2024-11-18

Conditions

Pyoderma Gangrenosum

Interventions

BIOLOGICAL

No Results Yet

NCT05105841 | COMPLETED | PHASE2

20 participants

Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax in Combination With Intravenous (IV) Obinutuzumab or Oral Ibrutinib in Adult Participants With Untreated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-11-08
Completion:: 2025-10-09

Conditions

Chronic Lymphocytic Leukemia (CLL)
Small Lymphocytic Lymphoma (SLL)

Interventions

DRUG

No Results Yet

NCT05097989 | TERMINATED | PHASE2

100 participants

Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-01-14
Completion:: 2024-12-09

Conditions

Lupus Nephritis
Immunoglobulin A Nephropathy
IgAN
LN

Interventions

DRUG

Results Available

NCT05067504 | COMPLETED | NA

50 participants

Effectiveness and Safety of the Octave System for Lifting the Eyebrow and Improving the Appearance of the Face and Neck

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-05-24
Completion:: 2022-08-17

Conditions

Eyebrow Lift
Improved Appearance of the Face and Neck

Interventions

DEVICE

Results Available

NCT05065502 | COMPLETED | NA

24 participants

MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-05-03
Completion:: 2024-03-06

Conditions

Polypharmacy
Insomnia
Anticoagulants

Interventions

BEHAVIORAL

Results Available

NCT05064553 | ACTIVE_NOT_RECRUITING

2990 participants

ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-07-26
Completion:: 2025-09-12

Conditions

Hepatocellular Carcinoma
Hepatocellular Cancer
Hepatitis B
Cirrhosis
Liver Cancer

Interventions

DEVICE
DIAGNOSTIC_TEST

No Results Yet

NCT05037097 | COMPLETED | PHASE1/PHASE2

72 participants

A Trial Evaluating the Safety and Immunogenicity of 3 COVID-19 SARS-CoV-2 RNA Vaccines in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-08-30
Completion:: 2023-12-19

Conditions

COVID-19
SARS-CoV-2 Infection
Corona Virus Infection

Interventions

BIOLOGICAL

Results Available

NCT05025085 | COMPLETED | PHASE1

25 participants

A Study Investigating AGEN1777 in Participants With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-10-04
Completion:: 2023-07-11

Conditions

Advanced Cancer

Interventions

DRUG

No Results Yet

NCT04994873 | RECRUITING | NA

216 participants

Skills to Enhance Positivity in Suicidal Youth

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-10-04
Completion:: 2026-07-01

Conditions

Suicide, Attempted

Interventions

BEHAVIORAL

No Results Yet

NCT04815863 | COMPLETED

9110 participants

Assessment of Somatic Symptom in Chinese Community-Dwelling People

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-03-01
Completion:: 2019-06-30

Conditions

Somatization Disorder

Interventions

DIAGNOSTIC_TEST

Results Available

NCT04800159 | ACTIVE_NOT_RECRUITING | PHASE2

40 participants

Cannabis Effects on Antiretroviral Therapy Pharmacokinetics and Neurotoxicity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-02-19
Completion:: 2025-10-30

Conditions

HIV
Cannabis Use

Interventions

DRUG

No Results Yet

NCT04797286 | RECRUITING | PHASE2

30 participants

Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-09-20
Completion:: 2026-09-01

Conditions

Scleroderma
Mildly Elevated Pulmonary Pressures

Interventions

DRUG
OTHER

No Results Yet

NCT04763876 | COMPLETED | PHASE4

110 participants

Intramuscular Ketorolac at Two Single-Dose Regimens

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-06-27
Completion:: 2020-11-09

Conditions

Musculoskeletal Pain
Analgesia
Adverse Event

Interventions

DRUG

Results Available

NCT04725006 | WITHDRAWN

0 participants

Sensory Responses to Dorsal Root Stimulation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-12-16
Completion:: 2025-07-11

Conditions

Amputation
Sensation, Phantom

Interventions

DEVICE

No Results Yet

NCT04695925 | ACTIVE_NOT_RECRUITING | PHASE3

294 participants

Osimertinib Monotherapy or Combination With Chemotherapy for Advanced NSCLC Concurrent EGFR and TP53 Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-03-29
Completion:: 2025-11-01

Conditions

Non-small Cell Carcinoma
EGFR Gene Mutation

Interventions

DRUG

No Results Yet

NCT04678336 | TERMINATED | PHASE1

12 participants

CD123 Redirected T Cells for AML in Pediatric Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-04-02
Completion:: 2025-05-09

Conditions

Acute Myeloid Leukemia, in Relapse
Acute Myeloid Leukemia, Pediatric
Acute Myeloid Leukemia, Refractory

Interventions

BIOLOGICAL

No Results Yet

NCT04645810 | WITHDRAWN | NA

0 participants

A Study of Focal Salvage High-Dose-Rate Brachytherapy for Prostate Gland Only Recurrence

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-10-29
Completion:: 2025-08-04

Conditions

Prostate Cancer
HDR

Interventions

PROCEDURE

No Results Yet

NCT04632654 | RECRUITING | NA

150 participants

A Motion Exergaming Approach for Symptom Management: HNC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-08-21
Completion:: 2026-11-30

Conditions

Head and Neck Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT04627428 | RECRUITING | PHASE1/PHASE2

18 participants

Safety and Tolerability of RPE Stem Cell-derived RPE(RPESC-RPE) Transplantation in Patients With Dry Age-related Macular Degeneration (AMD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-04-05
Completion:: 2026-12-01

Conditions

Dry Age-related Macular Degeneration

Interventions

BIOLOGICAL

No Results Yet

NCT04586959 | RECRUITING | NA

278 participants

Uterine Manipulation During Minimally Invasive Surgery for Early Stage Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-05-21
Completion:: 2027-07-31

Conditions

ENDOMETRIAL CANCER

Interventions

DEVICE

No Results Yet

NCT04557124 | COMPLETED | NA

113 participants

USS Training to Improve Social Function in People With Psychosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-12-01
Completion:: 2024-09-30

Conditions

Psychosis

Interventions

BEHAVIORAL

Results Available

NCT04533646 | COMPLETED | PHASE4

13 participants

Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-09-15
Completion:: 2023-07-31

Conditions

Cystic Fibrosis-related Diabetes

Interventions

DRUG
DEVICE

Results Available

NCT04510857 | COMPLETED | NA

25 participants

Motivating Occupational Virtual Experiences In Therapy for Kids

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-06-17
Completion:: 2024-06-15

Conditions

Virtual Reality
Occupational Therapy

Interventions

DEVICE
BEHAVIORAL

Results Available

NCT04500574 | TERMINATED | PHASE1

1 participants

Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2024-04-03
Completion:: 2025-10-10

Conditions

Glaucoma
Ocular Hypertension

Interventions

DRUG

No Results Yet