Clinical Trials Updated in 2025

NCT04790682 | RECRUITING | NA

300 participants

LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-05-22
Completion:: 2029-06-03

Conditions

Metastatic Lung Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT04779008 | RECRUITING | NA

210 participants

Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-03-10
Completion:: 2025-12-01

Conditions

Coronary Disease

Interventions

OTHER

No Results Yet

NCT04774523 | COMPLETED | NA

198 participants

Evaluation of the BIOTRONIK AutoAdapt Algorithm for Continuous Automatic Adaptive Cardiac Resynchronization

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-08-31
Completion:: 2024-07-31

Conditions

Heart Failure
Cardiac Arrhythmia
Left Ventricular Dysfunction

Interventions

PROCEDURE
OTHER

No Results Yet

NCT04762680 | COMPLETED | PHASE2/PHASE3

3159 participants

Study of Recombinant Protein Vaccines With Adjuvant as a Primary Series and as a Booster Dose Against COVID-19 in Adults 18 Years of Age and Older

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-02-24
Completion:: 2023-06-29

Conditions

COVID-19

Interventions

BIOLOGICAL

Results Available

NCT04746664 | COMPLETED | NA

210 participants

Effects of Nutrition Counselling on Old Age People's Nutritional Status and Quality of Life

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2022-01-28
Completion:: 2022-02-14

Conditions

Malnutrition
Quality of Life

Interventions

BEHAVIORAL

No Results Yet

NCT04726852 | COMPLETED

43 participants

Arterial Pressure vs. TE Echo dp/dt

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-02-02
Completion:: 2024-10-01

Conditions

Myocardial Contraction

Interventions

DEVICE

No Results Yet

NCT04701281 | TERMINATED | PHASE1/PHASE2

5 participants

Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2022-03-02
Completion:: 2022-09-19

Conditions

Liver Metastasis Colon Cancer

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04686435 | COMPLETED

1100 participants

Metabolic Syndrome and Persistent Shoulder Pain 1 Year After Primary Diagnosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-01-04
Completion:: 2025-01-04

Conditions

Shoulder Pain
Metabolic Syndrome

Interventions

OTHER
PROCEDURE

No Results Yet

NCT04569903 | WITHDRAWN | EARLY_PHASE1

0 participants

Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2022-08-01
Completion:: 2025-02-01

Conditions

Transthyretin Amyloidosis

Interventions

DEVICE

No Results Yet

NCT04560517 | RECRUITING

275 participants

Remission Factors in Anorexia Nervosa

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-04-06
Completion:: 2026-10-31

Conditions

Anorexia Nervosa

No Results Yet

NCT04548596 | COMPLETED

162 participants

NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2014-09-10
Completion:: 2025-04-30

Conditions

Traumatic Brain Injury
Subarachnoid Hemorrhage
Intracerebral Hemorrhage
Liver Failure
Ischemic Stroke

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04521972 | RECRUITING | NA

100 participants

Impact of Room Light on Uterine Contractions and Labor Progression in Pregnancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2025-09-01
Completion:: 2027-09-01

Conditions

Pregnancy Related
Labor; Poor
Uterine Contractions Weak

Interventions

DEVICE

No Results Yet

NCT04481893 | COMPLETED | NA

82 participants

Interest of the Virtual Reality Headset in the Management of Perioperative Stress in Patients Candidates for Total Thyroidectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-11-18
Completion:: 2025-06-06

Conditions

Thyroid Cancer
Thyroidectomy

Interventions

BEHAVIORAL

No Results Yet

NCT04447417 | COMPLETED | PHASE4

52 participants

Dupilumab Skin Barrier Function Study in Atopic Dermatitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-07-16
Completion:: 2021-06-17

Conditions

Atopic Dermatitis

Interventions

DRUG

Results Available

NCT04394663 | RECRUITING | NA

128 participants

High Dose Oral Omeprazole in High Risk UGIB

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-10-01
Completion:: 2025-05-30

Conditions

GI Bleeding

Interventions

DRUG

No Results Yet

NCT04383743 | COMPLETED | PHASE2

17 participants

Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-11-24
Completion:: 2024-06-17

Conditions

Stage II Bladder Cancer AJCC v8
Stage IIIA Bladder Cancer AJCC v8
Muscle Invasive Bladder Carcinoma

Interventions

DRUG
BIOLOGICAL
PROCEDURE

Results Available

NCT04380610 | COMPLETED

120 participants

Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-05-12
Completion:: 2025-06-30

Conditions

Sickle Cell Disease
Renal Disease
Glomerular Disease

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04365556 | COMPLETED | NA

72 participants

Using Technology-Assisted Stepped Care Intervention to Improve Adherence in Adolescents With Asthma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-11-19
Completion:: 2024-05-24

Conditions

Asthma

Interventions

BEHAVIORAL

Results Available

NCT04343521 | COMPLETED | NA

4461 participants

Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-11-03
Completion:: 2024-04-28

Conditions

Aedes-borne Diseases
Dengue
Chikungunya
Zika

Interventions

OTHER

Results Available

NCT04304339 | COMPLETED

862 participants

Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-12-14
Completion:: 2022-07-13

Conditions

Intensive Care Unit Syndrome
Hypercapnia
Acute Respiratory Failure

Interventions

OTHER

No Results Yet

NCT04295148 | RECRUITING | NA

200 participants

SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-02-10
Completion:: 2027-05-31

Conditions

Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Tear

Interventions

PROCEDURE

No Results Yet

NCT04291651 | RECRUITING

4000 participants

UCSF PANC Cyst Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-10-08
Completion:: 2030-01-01

Conditions

Pancreatic Cyst
Pancreatic Neoplasms
Pancreatic Cancer
Pancreatic Diseases
Pancreatic Intraductal Papillary Mucinous Neoplasm
Intraductal Papillary Mucinous Neoplasm
Pancreatic Ductal Adenocarcinoma
Mucinous Cyst

Interventions

OTHER

No Results Yet

NCT04280510 | RECRUITING

200 participants

Pathogenic Study of Adult Immune Enteropathies

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-02-27
Completion:: 2030-02-27

Conditions

Celiac Disease
Autoimmune Enteropathy
Inflammatory Bowel Diseases

Interventions

GENETIC

No Results Yet

NCT04258943 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

60 participants

Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-07-06
Completion:: 2028-07-31

Conditions

Philadelphia Chromosome Positive CML
Accelerated Phase Chronic Myelogenous Leukemia
Blastic Phase Chronic Myelogenous Leukemia
Chronic Phase Chronic Myelogenous Leukemia

Interventions

DRUG

No Results Yet

NCT04191382 | TERMINATED | PHASE2

105 participants

Phase 2 Window Study of SAR439859 (Amcenestrant) Versus Letrozole in Post-menopausal Patients With ER+, HER2- Pre-operative Post-menopausal Primary Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2020-02-04
Completion:: 2021-04-30

Conditions

Breast Cancer

Interventions

DRUG

Results Available

NCT04098354 | RECRUITING | NA

146 participants

Telemonitoring of Hypertensive Patients With Chronic Kidney Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2022-04-15
Completion:: 2026-12-31

Conditions

Chronic Kidney Diseases

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04079179 | RECRUITING | PHASE2

90 participants

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2021-04-19
Completion:: 2025-12-31

Conditions

Langerhan's Cell Histiocytosis
Juvenile Xanthogranuloma
Erdheim-Chester Disease
Rosai Dorfman Disease
Neuro-Degenerative Disease
Histiocytic Sarcoma
Histiocytic Disorders, Malignant

Interventions

DRUG

No Results Yet

NCT04053101 | COMPLETED

130 participants

Role of FDG-PET CT in the Management of Muscle Invasive Bladder Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2017-04-01
Completion:: 2018-12-31

Conditions

Muscle Invasive Bladder Cancer

Interventions

DEVICE

Results Available

NCT03971695 | COMPLETED | PHASE1

73 participants

A Study to Test How Well Healthy Men Tolerate Different Doses of BI 706321

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-06-18
Completion:: 2020-12-04

Conditions

Healthy

Interventions

DRUG

Results Available

NCT03965962 | COMPLETED | PHASE3

640 participants

Study of Purified Vero Rabies Vaccine Compared With Two Reference Rabies Vaccines in a Simulated Post-Exposure Regimen in Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-07-01
Completion:: 2020-12-22

Conditions

Rabies (Healthy Volunteers)

Interventions

BIOLOGICAL

Results Available

NCT03913754 | COMPLETED

160 participants

Psycho-social Consequences of Systemic Lupus Erythematosus

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-06-30
Completion:: 2020-04-22

Conditions

Lupus Erythematosus

Interventions

OTHER

No Results Yet

NCT03795298 | COMPLETED | NA

1600 participants

Comparison of Anticoagulation With Left Atrial Appendage Closure After AF Ablation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-05-20
Completion:: 2024-07-24

Conditions

Atrial Fibrillation

Interventions

DEVICE
DRUG

Results Available

NCT03721341 | ACTIVE_NOT_RECRUITING | PHASE3

204 participants

Stereotactic Ablative Radiotherapy for Comprehensive Treatment of 4-10 Oligometastatic Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-02-22
Completion:: 2029-01-31

Conditions

Metastatic Tumors

Interventions

RADIATION
DRUG
OTHER

No Results Yet

NCT03642821 | COMPLETED

300 participants

Intracranial Aneurysms Treatment With the OPTIMA Coil System

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2019-03-01
Completion:: 2021-10-13

Conditions

Intracranial Aneurysm
Coiling Therapy

Interventions

DEVICE

No Results Yet

NCT03548792 | ACTIVE_NOT_RECRUITING | NA

185 participants

Comparison of an Old Versus a New Total Knee Replacement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2017-05-18
Completion:: 2029-07-05

Conditions

Osteoarthritis Knee

Interventions

RADIATION
BEHAVIORAL

No Results Yet

NCT03485378 | ACTIVE_NOT_RECRUITING | NA

39 participants

Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2018-09-20
Completion:: 2022-01-11

Conditions

Non Small Cell Lung Cancer
Interstitial Lung Disease

Interventions

RADIATION

No Results Yet

NCT03446040 | TERMINATED | PHASE1/PHASE2

92 participants

An Investigational Immunotherapy Study of BMS-986258 Alone and in Combination With Nivolumab in Participants With Solid Cancers That Are Advanced or Have Spread

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2018-03-08
Completion:: 2024-08-29

Conditions

Advanced Cancer

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03405779 | RECRUITING

10 participants

A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-18
Start Date:: 2018-03-12
Completion:: 2026-01-01

Conditions

Mechanical Ventilation Complication
Ventilator-Induced Lung Injury

Interventions

PROCEDURE

No Results Yet

NCT03306680 | ACTIVE_NOT_RECRUITING | PHASE1

30 participants

SUNSET: SBRT for Ultra-central NSCLC- a Safety and Efficacy Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2018-01-19
Completion:: 2021-04-19

Conditions

Non Small Cell Lung Cancer

Interventions

RADIATION

No Results Yet

NCT03102294 | COMPLETED | NA

32 participants

Inspiratory Muscle Training in Pulmonary Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-18
Start Date:: 2017-09-01
Completion:: 2024-12-30

Conditions

Chronic Thromboembolic Pulmonary Hypertension
Inspiratory Muscle Training
Inspiratory Muscle Weakness
Pulmonary Arterial Hypertension

Interventions

OTHER

No Results Yet