Clinical Trials Updated in 2025

NCT04784221 | WITHDRAWN | PHASE2

0 participants

Nanoparticles and Hypofractionated Protontherapy for Reirradiation of Pantumor Relapse

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2021-03-31
Completion:: 2027-09-30

Conditions

Recurrent Cancer
Previous Radiation

Interventions

RADIATION

No Results Yet

NCT04705051 | TERMINATED | PHASE3

24 participants

Long-term Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) With Venglustat

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2021-02-09
Completion:: 2021-07-13

Conditions

Congenital Cystic Kidney Disease

Interventions

DRUG

Results Available

NCT04581980 | COMPLETED | NA

40 participants

Effects of Obesity and Intensity of Exercise on Ghrelin Levels

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-10-14
Completion:: 2025-04-16

Conditions

Obesity
Insulin Resistance
Cardiovascular Risk Factor

Interventions

OTHER

No Results Yet

NCT04547504 | ACTIVE_NOT_RECRUITING | PHASE3

349 participants

PEmbRolizumab verSus chEmotherapy and pEmbrolizumab in Non-small-cell Lung Cancers (NSCLC) With PDL1 ≥ 50 %

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-12-22
Completion:: 2025-12-22

Conditions

Non-small-cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT04537208 | COMPLETED | PHASE1/PHASE2

441 participants

Study of Recombinant Protein Vaccine Formulations Against COVID-19 in Healthy Adults 18 Years of Age and Older

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-09-03
Completion:: 2021-11-19

Conditions

COVID-19 (Healthy Volunteers)

Interventions

BIOLOGICAL

Results Available

NCT04519489 | TERMINATED | NA

129 participants

The Efficacy of PAP Therapy on Reducing AF Recurrence in Patients With Morbidity of OSA

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-09-18
Completion:: 2021-12-24

Conditions

Atrial Fibrillation
Obstructive Sleep Apnea

Interventions

DEVICE
OTHER

No Results Yet

NCT04507737 | RECRUITING | NA

1500 participants

Rapid Response Teams - How and Who?

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2021-09-01
Completion:: 2025-12-30

Conditions

Hospital Rapid Response Team
Early Warning Score
Intensive Care Units

Interventions

OTHER

No Results Yet

NCT04480450 | WITHDRAWN | PHASE2

0 participants

Rituximab in Chronic Inflammatory Demyelinating Polyneuropathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2025-07-31
Completion:: 2025-09-30

Conditions

Chronic Inflammatory Demyelinating Polyneuropathy

Interventions

DRUG

No Results Yet

NCT04451954 | COMPLETED | PHASE1

210 participants

Study of Recombinant Influenza Vaccine Containing Different H3 Antigens Without or With Adjuvant in Healthy Adult Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-07-02
Completion:: 2021-09-20

Conditions

Influenza Immunisation
Healthy Volunteers

Interventions

BIOLOGICAL

No Results Yet

NCT04392947 | COMPLETED | NA

238 participants

Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-09-29
Completion:: 2025-05-28

Conditions

Major Depressive Disorder

Interventions

DEVICE

No Results Yet

NCT04372641 | WITHDRAWN | PHASE1

0 participants

Testing the Safety of CB-5339 in Patients With Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-06-18
Completion:: 2021-07-12

Conditions

Aggressive Non-Hodgkin Lymphoma
Indolent Non-Hodgkin Lymphoma
Locally Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm

Interventions

DRUG

No Results Yet

NCT04298658 | COMPLETED

171 participants

The Impact of Insomnia on Pain in HIV

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-01-01
Completion:: 2025-07-31

Conditions

HIV
Insomnia

Interventions

DIAGNOSTIC_TEST
OTHER

No Results Yet

NCT04294459 | TERMINATED | PHASE1/PHASE2

23 participants

Safety, Pharmacokinetics, and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-06-18
Completion:: 2022-05-02

Conditions

Immune System Disorder

Interventions

DRUG

Results Available

NCT04292847 | COMPLETED

5 participants

LCCC1931:Post-treatment Intervention in Women With Breast Cancer (70y/o+)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-03-12
Completion:: 2024-05-20

Conditions

Breast Cancer

Interventions

OTHER

No Results Yet

NCT04253483 | ACTIVE_NOT_RECRUITING | PHASE2

14 participants

Comparison of High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy for the Treatment of Localized Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-07-17
Completion:: 2026-09-01

Conditions

Stage I Prostate Cancer AJCC v8
Stage II Prostate Cancer AJCC v8
Stage IIA Prostate Cancer AJCC v8
Stage IIB Prostate Cancer AJCC v8
Stage IIC Prostate Cancer AJCC v8

Interventions

RADIATION
OTHER
PROCEDURE

No Results Yet

NCT04229160 | ACTIVE_NOT_RECRUITING | NA

50 participants

Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-06-09
Completion:: 2025-06-24

Conditions

Atrial Fibrillation, Persistent

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT04211181 | RECRUITING | NA

5800 participants

CHIPs-VTE Study in Hospitalized Patients to Prevent Hospital-Acquired Venous Thromboembolism

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2025-08-01
Completion:: 2026-08-31

Conditions

Venous Thromboembolic Disease
Pulmonary Embolism
Venous Thromboembolism
Deep Venous Thrombosis
Quality Improvement

Interventions

OTHER

No Results Yet

NCT04202679 | COMPLETED | PHASE3

160 participants

Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (PRIME2)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-01-16
Completion:: 2021-08-30

Conditions

Neurodermatitis

Interventions

DRUG

Results Available

NCT04201119 | COMPLETED | NA

70 participants

Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-02-28
Completion:: 2023-11-17

Conditions

Surgery
Cardiac Event

Interventions

DEVICE

No Results Yet

NCT04183335 | COMPLETED | PHASE3

151 participants

Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (LIBERTY-PN PRIME)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-12-12
Completion:: 2021-11-12

Conditions

Neurodermatitis

Interventions

DRUG

Results Available

NCT04166903 | COMPLETED

277 participants

Prospective Follow-up, Marathon, Long Term, Inflammation and Cardiovascular System

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-11-15
Completion:: 2020-10-05

Conditions

Participants of the Be-MaGIC-Study 2009

No Results Yet

NCT04161495 | COMPLETED | PHASE3

159 participants

A Phase 3 Open-label Interventional Study of Intravenous Recombinant Coagulation Factor VIII Fc-von Willebrand Factor-XTEN Fusion Protein, Efanesoctocog Alfa (BIVV001), in Patients With Severe Hemophilia A

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-11-19
Completion:: 2022-02-03

Conditions

Factor VIII Deficiency

Interventions

BIOLOGICAL

Results Available

NCT04137887 | TERMINATED | PHASE3

33096 participants

Study to Evaluate the Effectiveness of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Adults 65 Years of Age and Older

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-11-04
Completion:: 2020-05-31

Conditions

Influenza (Healthy Volunteers)

Interventions

BIOLOGICAL

Results Available

NCT04040569 | ACTIVE_NOT_RECRUITING | PHASE1

45 participants

A Phase I Dose Escalation Study of Single Fraction Pre-operative Partial Breast (S-PBI) for Early Stage Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-12-25
Completion:: 2027-07-31

Conditions

Breast Cancer

Interventions

RADIATION

No Results Yet

NCT04034810 | ACTIVE_NOT_RECRUITING

234 participants

Safety and Efficacy of Silk Vista and Silk Vista Baby Flow Diverter for Intracranial Aneurysm Treatment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-11-04
Completion:: 2023-03-01

Conditions

Intracranial Aneurysm
Flow Diverter

Interventions

DEVICE

No Results Yet

NCT04033367 | COMPLETED | PHASE4

188 participants

SAR231893-LPS15497- "Dupilumab Effect on Sleep in AD Patients"

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-08-22
Completion:: 2021-10-06

Conditions

Atopic Dermatitis

Interventions

DRUG

Results Available

NCT04027972 | COMPLETED | EARLY_PHASE1

13 participants

Pharmacokinetics of Neostigmine and Glycopyrrolate

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2020-03-09
Completion:: 2022-12-20

Conditions

Spinal Cord Injuries
Constipation
Fecal Incontinence
Neurogenic Bowel

Interventions

DRUG
DEVICE

No Results Yet

NCT03977129 | ACTIVE_NOT_RECRUITING | NA

792 participants

Quantitative Flow Ratio (QFR) Guided Coronary Artery Bypass Grafting for Patients Undergoing Primary Valve Surgery With Concomitant Coronary Artery Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-08-04
Completion:: 2024-09-30

Conditions

Primary Valvular Heart Disease With Comorbid Coronary Artery Disease
Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease

Interventions

DEVICE
OTHER

No Results Yet

NCT03964402 | COMPLETED

500 participants

Sample Size for Multivariate Time-to-event Data

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-01-01
Completion:: 2024-12-31

Conditions

Clinical Trials

No Results Yet

NCT03949972 | RECRUITING

500 participants

The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-04-01
Completion:: 2028-03-31

Conditions

Glomerulosclerosis, Focal Segmental
Minimal Change Disease
Idiopathic Nephrotic Syndrome

Interventions

OTHER

No Results Yet

NCT03889639 | COMPLETED | PHASE2

130 participants

Dose-finding Study for SAR442168 in Relapsing Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-03-29
Completion:: 2020-01-02

Conditions

Relapsing Multiple Sclerosis

Interventions

DRUG

Results Available

NCT03844906 | COMPLETED | PHASE1

40 participants

A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-12-27
Completion:: 2019-03-18

Conditions

Healthy Volunteer

Interventions

DRUG

No Results Yet

NCT03822013 | TERMINATED | PHASE3

30 participants

Effects of Miglustat Therapy on Infantile Type of Sandhoff and Taysachs Diseases (EMTISTD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-01-14
Completion:: 2025-09-10

Conditions

GM2 Gangliosidosis
Supportive Care

Interventions

DRUG

No Results Yet

NCT03790241 | COMPLETED | NA

31 participants

In Vivo Biomechanical Analysis of the Practitioner's Motion During a Peripheral Venous Catheter Insertion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-04-25
Completion:: 2020-02-14

Conditions

Healthy

Interventions

PROCEDURE

No Results Yet

NCT03787758 | COMPLETED | PHASE1

6 participants

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2019-02-28
Completion:: 2019-10-07

Conditions

Huntington Disease

Interventions

DRUG

No Results Yet

NCT03771586 | COMPLETED | PHASE1

22 participants

A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-09-24
Completion:: 2018-12-17

Conditions

Healthy Volunteer

Interventions

DRUG

No Results Yet

NCT03770780 | COMPLETED | PHASE1

19 participants

A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-11-12
Completion:: 2019-03-08

Conditions

Healthy Volunteer

Interventions

DRUG

No Results Yet

NCT03692897 | TERMINATED

1708 participants

An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-10-11
Completion:: 2025-09-10

Conditions

Hepatitis B
Hepatitis
Liver Diseases

Interventions

OTHER

No Results Yet

NCT03564626 | COMPLETED | NA

232 participants

Health IT Generated PROs to Improve Outcomes in Cirrhosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-06-22
Completion:: 2024-04-22

Conditions

Cirrhosis

Interventions

OTHER

Results Available

NCT03545906 | COMPLETED | NA

326 participants

Telemedicine Enhanced Asthma Management - Uniting Providers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-17
Start Date:: 2018-11-09
Completion:: 2024-05-06

Conditions

Asthma in Children

Interventions

OTHER

Results Available