Clinical Trials Updated in 2025

NCT05013554 | TERMINATED | PHASE1

44 participants

Dose Escalation and Expansion Study of SAR443216 in Participants With Relapsed/Refractory HER2 Expressing Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-08-16
Completion:: 2024-01-15

Conditions

Neoplasm Malignant
Breast Cancer
Lung Neoplasm Malignant
Gastric Cancer
Neoplasm

Interventions

DRUG

No Results Yet

NCT04961047 | COMPLETED | NA

36 participants

Feasibility and Efficacy of a Digital Neurotherapy Protocol for Management of Depression, Cognition, and Quality of Life in Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-12-17
Completion:: 2025-05-30

Conditions

Depression
Cognition
Quality of Life

Interventions

BEHAVIORAL

No Results Yet

NCT04950218 | RECRUITING

1000 participants

Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-09-01
Completion:: 2034-10-01

Conditions

Psoriasis
Cardiovascular Diseases
Cardiovascular Risk Factor
Cardiovascular Pathology
Psoriasis Vulgaris
Psoriatic Nail
Psoriasis Face
Psoriasis Guttate
Psoriasis Gyrata
Psoriasis Diffusa
Psoriasis Palmaris
Psoriasis Annularis
Psoriasis Circinata
Psoriasis Plantaris
Psoriasis Universalis
Psoriasis Geographica
Left Ventricular Dysfunction
Myocardial Infarction
Myocardial Ischemia
Heart Failure
Stroke
Heart Diseases
Heart Failure, Systolic
Heart Failure, Diastolic

No Results Yet

NCT04943874 | COMPLETED | NA

93 participants

Biofeedback Based Virtual Reality Intervention to Manage Postoperative Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2022-03-10
Completion:: 2025-08-06

Conditions

Pain
Pain, Postoperative
Pain, Acute
Surgery

Interventions

DEVICE

No Results Yet

NCT04893954 | RECRUITING | NA

80 participants

Prospective Study on the Consequences of Weight Loss After Bariatric Surgery on Obese Patients' Spine.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-06-03
Completion:: 2027-07-31

Conditions

Low Back Pain in Obese Patients After Important Weight Loss

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04871919 | ACTIVE_NOT_RECRUITING

1304 participants

Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-05-11
Completion:: 2028-06-30

Conditions

Rheumatoid Arthritis

Interventions

DRUG

No Results Yet

NCT04863703 | ACTIVE_NOT_RECRUITING

11 participants

Improvement of Portal Hypertension During Viral Suppression in Patients With Hepatitis Delta (IMPHROVE-D)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-05-07
Completion:: 2024-11-30

Conditions

Hepatitis D
Hepatitis B
Portal Hypertension
Liver Cirrhosis

Interventions

DRUG

No Results Yet

NCT04861506 | RECRUITING

400 participants

The Safety and Efficiency of Endovascular Treatment of Acute or Subacute Thromboembolic Occlusions of Lower Extremity.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-04-01
Completion:: 2025-12-31

Conditions

Thromboembolic Disease
Lower Extremity Problem
Endovascular Treatment
Safety Issues
Efficacy, Self

Interventions

PROCEDURE

No Results Yet

NCT04861402 | COMPLETED

60 participants

Non-Invasive Intracranial Pressure in COVID-19 Individuals

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-04-30
Completion:: 2021-07-15

Conditions

Intracranial Pressure

Interventions

DEVICE

No Results Yet

NCT04833348 | ACTIVE_NOT_RECRUITING | NA

35 participants

Quantification of Motor Function in Infants With Spinal Muscular Atrophy Treated With Innovative Therapies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-03-20
Completion:: 2025-03-17

Conditions

Spinal Muscular Atrophy

Interventions

OTHER

No Results Yet

NCT04822987 | ACTIVE_NOT_RECRUITING

120 participants

Factors Predicting Outcome in Group Treatment of Alcohol Use Disorders (AUDs)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-02-01
Completion:: 2026-01-01

Conditions

Alcohol Use Disorder (AUD)
Alcohol Abuse
Drug Abuse
Psychiatric Disorder
Personality Disorders
Cognitive Deficit
Cognitive Impairment
Substance Use Disorders

No Results Yet

NCT04820283 | COMPLETED | NA

172 participants

Early Interventions for Primary Care Patients With Stress-related Ill-health: a Non-inferiority RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-04-29
Completion:: 2025-07-07

Conditions

Stress

Interventions

BEHAVIORAL

No Results Yet

NCT04816734 | COMPLETED | NA

11 participants

Initial Parenteral Nutrition Education of Parent Assessment Plan

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-03-25
Completion:: 2021-09-25

Conditions

Parenteral Nutrition

Interventions

OTHER

No Results Yet

NCT04797273 | COMPLETED | NA

300 participants

Internet-based CBT vs. TAU for Stress-related Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-03-25
Completion:: 2024-06-01

Conditions

Adjustment Disorders
Exhaustion Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT04718870 | COMPLETED | PHASE4

41 participants

Dupilumab-PEdiatric Skin Barrier Function and LIpidomics STudy in Patients With Atopic Dermatitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-02-19
Completion:: 2022-09-07

Conditions

Dermatitis Atopic

Interventions

DRUG

Results Available

NCT04694196 | COMPLETED | NA

40 participants

Use of Anatomical Landmark in Locate Occlusal Plane.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-09-20
Completion:: 2021-11-01

Conditions

Dentulous

Interventions

DEVICE

No Results Yet

NCT04677491 | COMPLETED | PHASE4

25 participants

Effects of Ospemifene on Brain Activation Patterns in Women With Sexual Interest-arousal Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-11-01
Completion:: 2022-11-01

Conditions

Vulvovaginal Signs and Symptoms
Genitourinary Syndrome of Menopause
Sexual; Disorder, Arousal, Female

Interventions

DRUG
BEHAVIORAL

No Results Yet

NCT04661124 | COMPLETED

88 participants

Evaluation of the Heidelberg Engineering SPECTRALIS With Flex Module for In-vivo Imaging in the Supine Position

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-12-10
Completion:: 2021-09-17

Conditions

Retinal Disease
Healthy Eyes

Interventions

DEVICE

No Results Yet

NCT04656600 | COMPLETED | PHASE4

12 participants

Study to Evaluate Efficacy and Safety of Imiglucerase Treatment in Chinese Patients With Gaucher Disease Type Ⅲ

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-03-02
Completion:: 2023-10-12

Conditions

Gaucher's Disease

Interventions

DRUG

No Results Yet

NCT04649151 | COMPLETED | PHASE2/PHASE3

4328 participants

A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-12-09
Completion:: 2024-06-14

Conditions

SARS-CoV-2

Interventions

BIOLOGICAL

Results Available

NCT04649034 | COMPLETED

258 participants

Intraventricular Stasis In Cardiovascular Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-11-24
Completion:: 2024-12-31

Conditions

Dilated Cardiomyopathy
Thrombosis Cardiac
Stroke
Hypertrophic Cardiomyopathy

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04606693 | RECRUITING | NA

50 participants

Value of Screening and Treatment of SAHS in the Management of AF Ablation Candidates

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-11-05
Completion:: 2026-12-31

Conditions

Atrial Fibrillation Paroxysmal
Atrial Fibrillation, Persistent
Apnea Syndrome
Hypopnea Syndrome

Interventions

OTHER

No Results Yet

NCT04602624 | COMPLETED | PHASE2

26 participants

A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-12-07
Completion:: 2021-09-28

Conditions

Alzheimer Disease
Cognitive Dysfunction
Mild Dementia

Interventions

DRUG

Results Available

NCT04592003 | RECRUITING

1200 participants

French Colorectal ESD Cohort in Experts Centers

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-01-01
Completion:: 2026-01-01

Conditions

Cancer Colorectal
Polyps Colorectal
Endoscopic Submucosal Resection

Interventions

PROCEDURE

No Results Yet

NCT04589403 | COMPLETED | PHASE1

14 participants

1a/1b Study of OPT101 First in Human Study Assessing Safety and Tolerability of 15-mer Peptide.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-02-18
Completion:: 2021-09-27

Conditions

Healthy

Interventions

DRUG

No Results Yet

NCT04583761 | COMPLETED

622 participants

Tobacco and Nicotine Consumption and the Risk of Acquisition of Coronavirus Disease 2019 (COVID-19)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-10-14
Completion:: 2021-02-06

Conditions

COVID-19

Interventions

BEHAVIORAL

No Results Yet

NCT04575025 | COMPLETED

109 participants

Special Drug Use-results Surveillance of Tabrecta Tablets

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-11-02
Completion:: 2024-10-26

Conditions

Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT04521166 | COMPLETED | NA

42 participants

Hearing Aid Processing and Working Memory in Realistic Spatial Conditions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2021-05-06
Completion:: 2023-06-29

Conditions

Hearing Loss, Sensorineural

Interventions

DEVICE

Results Available

NCT04515459 | RECRUITING | PHASE2

53 participants

Efficacy of Pre-operative Prehabilitation in Patients With Limb Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2022-09-13
Completion:: 2029-11-30

Conditions

Sarcoma

Interventions

OTHER

No Results Yet

NCT04482179 | COMPLETED | PHASE1

23 participants

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-02-19
Completion:: 2024-08-31

Conditions

Alzheimer Disease

Interventions

DEVICE
BEHAVIORAL

Results Available

NCT04476017 | COMPLETED | PHASE2

18 participants

A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Parkinson's Disease Mild Cognitive Impairment (PD-MCI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-07-31
Completion:: 2022-03-25

Conditions

Parkinson Disease
Cognitive Dysfunction

Interventions

DRUG

Results Available

NCT04466891 | COMPLETED | PHASE2

87 participants

A Study of ZW25 (Zanidatamab) in Subjects With Advanced or Metastatic HER2-Amplified Biliary Tract Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-10-01
Completion:: 2023-07-28

Conditions

HER2-amplified Biliary Tract Cancers

Interventions

DRUG

Results Available

NCT04464187 | TERMINATED

173 participants

A Study to Evaluate Pregnancy Outcomes in Females Treated With Oral Elagolix Tablets and Capsules

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2022-01-06
Completion:: 2025-07-11

Conditions

Endometriosis
Uterine Fibrioids

No Results Yet

NCT04459806 | RECRUITING

250 participants

Intracranial PrEssure Time dOse (ImPETO)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2023-11-13
Completion:: 2026-11-30

Conditions

Intracranial Hypertension
Traumatic Brain Injury
Subarachnoid Hemorrhage
Intracranial Hemorrhages

Interventions

PROCEDURE

No Results Yet

NCT04447716 | ACTIVE_NOT_RECRUITING | PHASE1

4 participants

An Early Phase Study of Venetoclax, Lenalidomide, and Rituximab/Hyaluronidase in Slow-Growing Lymphomas That Have Come Back After Treatment or Have Not Responded to Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-10-16
Completion:: 2024-05-16

Conditions

Recurrent B-Cell Non-Hodgkin Lymphoma
Recurrent Follicular Lymphoma
Recurrent Indolent Adult Non-Hodgkin Lymphoma
Recurrent Marginal Zone Lymphoma
Refractory B-Cell Non-Hodgkin Lymphoma
Refractory Follicular Lymphoma
Refractory Indolent Adult Non-Hodgkin Lymphoma
Refractory Marginal Zone Lymphoma

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT04446260 | COMPLETED | PHASE1

396 participants

A Study of SHR-A1811 in Subjects With Advanced Malignant Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-09-07
Completion:: 2025-06-04

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT04420468 | COMPLETED

20 participants

Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-06-10
Completion:: 2022-05-31

Conditions

COVID-19

No Results Yet

NCT04397328 | WITHDRAWN | PHASE3

0 participants

COVID-19 PEP- High-risk Individuals in Long-term and Specialized Care - Canada

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-05-30
Completion:: 2021-04-30

Conditions

COVID-19

Interventions

DRUG

No Results Yet

NCT04389216 | COMPLETED | NA

30 participants

Radiofrequency Ablation (RFA) in Breast Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-05-01
Completion:: 2025-09-09

Conditions

Breast Cancer Female

Interventions

DEVICE

No Results Yet

NCT04385160 | COMPLETED

552 participants

Myeloproliferative Neoplasms (MPN) and COVID-19

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-15
Start Date:: 2020-05-13
Completion:: 2022-02-15

Conditions

Myeloproliferative Neoplasm
COVID

No Results Yet