HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport

Summary

The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.

The study will enroll patients undergoing prehospital, interhospital, or intrahospital transport while receiving advanced respiratory support, including high-flow nasal oxygen (HFNO), noninvasive ventilation (NIV), or invasive mechanical ventilation, as determined by routine clinical practice. The study protocol will not assign respiratory-support modalities, transport strategies, or therapeutic interventions.

The primary objective is to prospectively evaluate clinical, technical, organizational, and transport-related factors associated with the safe continuation of respiratory support throughout patient transport. Data collection will include patient characteristics, respiratory-support modality and settings, transport characteristics, physiologic monitoring, transport-team composition, oxygen and electrical power resources, equipment-related events, interruptions or modifications of respiratory support, clinical deterioration, rescue interventions, escalation of respiratory support, and other transport-associated adverse events.

HERMES Phase III constitutes the prospective multicenter component of a broader research program that previously included an international survey of respiratory-support transport practices and an exploratory prospective feasibility evaluation of portable external power during ambulance transport.

Conditions

• Acute Respiratory Failure
• Respiratory Insufficiency
• Respiratory Distress
• Critical Illness
• Chronic Respiratory Failure
• Cardiorespiratory Failure
• Mechanical Ventilation
• Noninvasive Ventilation
• High-Flow Nasal Oxygen Therapy
• Advanced Respiratory Support
• Patient Transport
• Transport of Critically Ill Patients
• Patient Safety During Transport
• Patient Safety

Interventions

OTHER

Advanced Respiratory Support During Patient Transport

Exposure to advanced respiratory support during prehospital, interhospital, or intrahospital transport, including high-flow nasal oxygen, noninvasive ventilation, or invasive mechanical ventilation, as determined by routine clinical practice. No respiratory-support modality is assigned by the study protocol.

Sponsors & Collaborators

• International Association of Non Invasive Ventilation

  collaborator UNKNOWN

• International Academy of Non Invasive Ventilation

  collaborator UNKNOWN

• International College of Non Invasive Ventilation

  collaborator UNKNOWN

• Medipol University

  lead OTHER

Principal Investigators

• Antonio M Esquinas · Intensive Care Unit, Hospital Meseguer, Murcia, Spain

• Berkan Basançelebi · İstanbul Medipol University, İstanbul, Türkiye

• Gaspar R. Chiappa · Faculty of Health Sciences, Universidad Autónoma de Chile, Providencia, Santiago, Chile

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-12-31

Primary Completion

2027-06-01

Completion

2027-12-31

Countries

• Colombia
• Egypt
• Qatar
• Turkey (Türkiye)

Study Locations