Comparing Advanced Technologies to Standard Testing for the Diagnosis of Airway Disease in Hospital and Community Settings

Summary

Airway disease, such as chronic obstructive pulmonary disease (COPD), is usually diagnosed through breathing tests like spirometry. However, it requires people to blow forcefully into a machine several times which can be uncomfortable and difficult for some patients.

This study is looking at whether newer technologies and other breathing tests can help diagnose COPD as accurately as standard testing. We will compare these tests in both hospital and community settings. We are interested in understanding how practical and cost-effective these tests are, including how easy they are to use and how comfortable they are for patients to perform.

Conditions

• COPD (Chronic Obstructive Pulmonary Disease)
• Airway Disease

Interventions

DIAGNOSTIC_TEST

Capnography

Capnography used in combination with machine learning-derived algorithms, with or without reversibility testing (if indicated on spirometry)

DIAGNOSTIC_TEST

Oscillometry

Oscillometry (where applicable), with or without reversibility testing (if indicated on spirometry). Measures respiratory impedance during normal tidal breathing.

DIAGNOSTIC_TEST

FENO

Fractional exhaled nitric oxide (if requested). Used to assess airway inflammation.

DIAGNOSTIC_TEST

Gas Transfer

Assesses lung diffusing capacity, performed using full pulmonary function testing equipment

DIAGNOSTIC_TEST

Static Lung Volumes

Body plethysmography (if applicable). Used to assess static lung volumes and, where applicable, specific resistance, performed using full lung function equipment

DIAGNOSTIC_TEST

Spirometry

Spirometry, with or without reversibility testing

Sponsors & Collaborators

• Hampshire Hospitals NHS Foundation Trust

  collaborator OTHER

• University of Southampton

  collaborator OTHER

• TidalSense

  collaborator INDUSTRY

• NIHR Southampton Respiratory Biomedical Research Centre

  collaborator UNKNOWN

• Restech Srl

  collaborator INDUSTRY

• University Hospital Southampton NHS Foundation Trust

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-08-31

Primary Completion

2027-08-31

Completion

2029-08-31

Countries

• United Kingdom

Study Locations