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Acceleration of Tooth Movement Using PRP and Photobiomodulation With Clear Aligners

NCT07795073 · Status: NOT_YET_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2026-08-31

No results posted yet for this study

Summary

This study compares the effectiveness of two adjunct therapies- photobiomodulation (low-level laser therapy) (PBM) and localized platelet-rich plasma (PRP) injections in accelerating orthodontic tooth movement. Participants receiving clear aligner therapy will be randomly assigned to one of three groups: clear aligners with PBM, clear aligners with PRP, or clear aligners alone (control group). The goal is to evaluate the efficiency, tooth movement tracking and safety.

Conditions

  • Orthodontic Tooth Movement

Interventions

BIOLOGICAL

Platelet Rich Plasma (PRP) injection

local submucosal injection of Autologous Platelet Rich Plasma (PRP) into the targeted alveolar site to evaluate its clinical effectiveness in accelerating orthodontic tooth movement

DEVICE

photobiomodulation (PBM) Therapy

extra-oral application of photobiomodulation (PBM) Therapy to the targeted alveolar site to evaluate its clinical effectiveness in accelerating orthodontic tooth movement

DEVICE

clear aligner(12-hour wear protocol)

Clear aligner worn for 22-hour on the first day of each aligner stage, followed by a daily wear duration of 12-hour per day for the remaining period in combination with acceleration modalities

DEVICE

Clear aligner(22-hour wear protocol)

Clear aligners worn for the standard conventional duration of 22-hour per day without additional acceleration interventions

Sponsors & Collaborators

  • Sana'a University

    lead OTHER

Principal Investigators

  • Arij L Abdulmajid, MSc · Sanaa University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2027-04-01
Completion
2027-05-01

Countries

  • Yemen

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07795073 on ClinicalTrials.gov