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Increasing Mitochondrial Respiration as a Novel Mechanism for Cognitive Augmentation

NCT07793604 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2026-08-28

No results posted yet for this study

Summary

The purpose of this study is to investigate the effects of increasing brain energy on cognition. The hypothesis is that by using a special kind of light, in combination with a nutritional supplement, it may be possible to increase energy production in the brain, which may lead to improvements in cognition.

Conditions

  • Cognition Improvement
  • Emotion Regulation

Interventions

DEVICE

Active transcranial photobiomodulation

Infrared light delivered to the forehead, administered with a headset using light-emitting diodes (LEDs)

DIETARY_SUPPLEMENT

Active MCT dietary supplementation

Commercially-available food-grade refined coconut oil for ketogenic dietary supplementation

DEVICE

Sham photobiomodulation

Identical procedure as active group, but with 5% of light emitted by the device.

DIETARY_SUPPLEMENT

Sham dietary supplementation

Identical appearance and administration as active dietary supplementation, but with commercially-available food-grade sunflower oil (comparable caloric value without ketone production).

Sponsors & Collaborators

  • Francisco Gonzalez-Lima, PhD

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-10-01
Primary Completion
2029-12-31
Completion
2030-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07793604 on ClinicalTrials.gov