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Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation

NCT07613970 · Status: NOT_YET_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-05-29

No results posted yet for this study

Summary

The goal of this interventional study is to understand the contribution of the central components to the manifestation of neuromuscular fatigue in stroke survivors. The study will include adults with a first-ever stroke in the subacute phase.

The main question it aims to answer:

• How does the brain activity contribute to the manifestation of neuromuscular fatigue in stroke survivors?

Researchers will compare stroke participants receiving active vs sham tACS in a single session before the fatiguing contractions to determine whether central changes can influence fatigue onset/progression.

Participants will:

* Perform repeated leg muscle contractions until fatigue while seated in an experimental setup
* Receive either active or sham tACS for 20 minutes before the fatiguing contractions.
* Wear non-invasive sensors to record brain activity (EEG) and muscle activity (EMG) during the task
* Complete the study during a single experimental session in which fatigue-related changes will be measured throughout the task

Conditions

  • Stroke
  • Cerebrovascular Accident (CVA)
  • Ischemia Stroke
  • Hemorrhage Stroke

Interventions

DEVICE

Transcranial alternating current stimulation (tACS)

Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that uses electrodes on the scalp to apply weak alternating electrical currents to the brain.

DEVICE

Sham treatment

mimics active tACS but stops after 1 minute

Sponsors & Collaborators

  • Vrije Universiteit Brussel

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2029-10-31
Completion
2029-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07613970 on ClinicalTrials.gov