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Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness

NCT07790302 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 7500

Last updated 2026-08-27

No results posted yet for this study

Summary

This study will look at how many children develop rheumatic heart disease (RHD) over a 3-year period. The study will include children ages 5 to 8 who do not have RHD at the start and who live in areas where the disease is common. Each child will have a heart ultrasound (echocardiogram) once a year for 3 years to check for signs of RHD. Doctors will diagnose RHD using internationally recognized guidelines from the World Heart Federation (2023). The study will also look at how often new cases occur each year, whether rates differ by age, sex, or location, and whether any children develop acute rheumatic fever during the study.

Conditions

  • Rheumatic Heart Disease in Children

Sponsors & Collaborators

  • Uganda Heart Institute

    collaborator OTHER

  • Murdoch Childrens Research Institute

    collaborator OTHER

  • Ochsner Health System

    collaborator OTHER

  • Malawi Liverpool Wellcome Programme

    collaborator OTHER

  • Children's Hospital Medical Center, Cincinnati

    lead OTHER

Principal Investigators

  • Andrea Beaton · Children's Hospital Medical Center, Cincinnati

Eligibility

Min Age
5 Years
Max Age
8 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2027-02-28
Primary Completion
2031-07-31
Completion
2032-03-01

Countries

  • Uganda

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07790302 on ClinicalTrials.gov