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Sensory and Physical Reactions to Beverage Cues

NCT07788716 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-08-26

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate changes in craving and sensory responses to different beverage cues in adults (aged 21-70) with current mild or greater alcohol use disorder (AUD). The main questions it aims to answer are:

* Does exposure to different beverage cues elicit distinct changes in subjective craving?
* How do beverage liking, peak craving, and the return of craving to baseline compare across different test-beverage conditions?

Researchers will compare Session A (Test Beverage Condition A) to Session B (Test Beverage Condition B) in a randomized crossover design to see if sensory and expectancy effects influence craving responses without consumption.

Participants will:

* Complete two separate 3-minute cue reactivity trials per session (a baseline water cue, followed by a test-beverage cue) while listening to guided audio instructions and holding/smelling the beverage without drinking it.
* Rate their craving and beverage liking using visual analog scales (VAS) immediately after each trial.
* Provide breathalyzer readings (BrAC), vital signs, and safety/medication checks at both study visits.
* Complete diagnostic and drinking history assessments (such as the SCID-5, TLFB, and ACQ-SF-R).

Conditions

  • Alcohol Use Disorder (AUD)

Interventions

BEHAVIORAL

Alcohol Cue Reactivity Paradigm

Standardized 3-minute visual, olfactory, and tactile exposure to beverage cues (water, and two similar appearing beverages) accompanied by guided audio instructions.

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-31
Primary Completion
2027-10-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07788716 on ClinicalTrials.gov