MedTrace Logo

Long-Term Clinical Results of Ab-Interno Trabeculotomy in Glaucoma Management

NCT07780916 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-08-25

No results posted yet for this study

Summary

Glaucoma is one of the leading causes of irreversible vision loss worldwide. Elevated intraocular pressure (IOP) is the most important risk factor for the development and progression of the disease.

Ab-interno trabeculotomy (AIT) using the Trabectome system is a minimally invasive glaucoma surgery (MIGS) that reduces aqueous humor outflow resistance by ablating the trabecular meshwork and the inner wall of Schlemm's canal, thereby lowering intraocular pressure.

Previous studies have demonstrated good short-term efficacy of this procedure. However, robust long-term data spanning several years remain scarce.

The aim of this study is to evaluate the long-term outcomes of AIT in glaucoma patients who underwent surgery between 2019 and 2021 at the Department of Ophthalmology, University Hospital Würzburg. Patients are invited for a single study visit at which intraocular pressure, visual acuity, anterior chamber angle by gonioscopy, and optic nerve structure by optical coherence tomography (OCT) are assessed. The collected data are compared with pre-operative baseline values obtained from medical records.

The results are intended to improve the assessment of long-term surgical success and to optimize patient selection for this procedure in the future.

Conditions

  • Glaucoma
  • Glaucoma Patient
  • GLAUCOMA 1, OPEN ANGLE, D (Disorder)
  • Glaucoma Following Surgery
  • Glaucoma Eye

Interventions

PROCEDURE

Ab-interno trabeculotomy

Ab-interno trabeculotomy (AIT) is a minimally invasive glaucoma surgery (MIGS) performed using the Trabectome device. The procedure ablates the trabecular meshwork and the inner wall of Schlemm's canal via an ab-interno approach, thereby reducing resistance to aqueous humor outflow and lowering intraocular pressure. The surgery is performed under local or general anesthesia and can be combined with cataract surgery. In this observational study, the intervention was performed prior to study enrollment; no surgical intervention is performed as part of the study itself.

Sponsors & Collaborators

  • Wuerzburg University Hospital

    lead OTHER

Principal Investigators

  • Raoul Verma-Führing, Dr. · Wuerzburg University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-03
Primary Completion
2026-11-01
Completion
2027-02-01

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07780916 on ClinicalTrials.gov