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How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play?

NCT07778511 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2026-08-21

No results posted yet for this study

Summary

The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.

Conditions

  • Stress
  • Early Life Stress
  • Sex Differences
  • Opioid

Interventions

DRUG

Morphine

Sevredol 10mg, oral single-dose administration

DRUG

Placebo

identical in appearance to active drug, containing no active substance (mannitol), oral one-time administration

Sponsors & Collaborators

  • Sara L. Kroll

    lead OTHER

Principal Investigators

  • Sara L Kroll, Dr. · Psychiatric University Hospital, Zurich

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-30
Primary Completion
2026-12-31
Completion
2028-03-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07778511 on ClinicalTrials.gov