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Comparative Study of Topical Pentoxifylline Versus Topical 5-Fluorouracil Combined With Microneedling and NB-UVB for Stable Vitiligo

NCT07775105 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2026-08-20

No results posted yet for this study

Summary

This randomized, single-blinded clinical trial evaluates the efficacy and safety of topical pentoxifylline compared with topical 5-fluorouracil, both combined with microneedling and narrow-band ultraviolet B (NB-UVB) phototherapy, in patients with stable vitiligo. A total of 42 patients with stable vitiligo received six biweekly microneedling sessions over three months, with concomitant NB-UVB phototherapy twice weekly, followed by a three-month follow-up period. Each patient had three vitiliginous patches allocated to topical pentoxifylline with microneedling, topical 5-fluorouracil with microneedling, or microneedling alone.

Conditions

  • Vitiligo Vulgaris
  • Microneedling-Assisted Delivery
  • Phototherapy

Interventions

COMBINATION_PRODUCT

Microneedling + topical treatment (PTX 20 mg/ml) followed by NB phototherapy

Microneedling + topical treatment (PTX 20 mg/ml) followed by NB phototherapy

COMBINATION_PRODUCT

Microneedling + topical treatment (5-FU 5%) followed by NB phototherapy

Microneedling + topical treatment (5-FU 5%) followed by NB phototherapy

PROCEDURE

Microneedling alone followed by NB phototherapy

Microneedling alone followed by NB phototherapy

Sponsors & Collaborators

  • Tanta University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
6 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2025-04-04
Completion
2025-06-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07775105 on ClinicalTrials.gov