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Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

NCT07548918 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-04-29

No results posted yet for this study

Summary

This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo.

It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo.

Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact.

The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin.

The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis

Conditions

  • Vitiligo - Macular Depigmentation

Interventions

COMBINATION_PRODUCT

microneedling with minoxidil 5% and NBUVB

Micronnedlin depth 1% then topical Minoxidil5% and Narrow Band UVB

COMBINATION_PRODUCT

Microneedling with Minoxidil5%

Microneedling with topical Minoxidil 5%

Sponsors & Collaborators

  • Sohag University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
16 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-20
Primary Completion
2027-02-15
Completion
2027-10-15

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07548918 on ClinicalTrials.gov