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Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.

NCT07766707 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 192

Last updated 2026-08-14

No results posted yet for this study

Summary

Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure. Current literature has highlighted the importance of systemic factors (such as vitamin D deficiency and osteoporosis) and local factors (such as the presence of nearby periapical infections or implant placement in sites with a history of endodontic failure) that affect bone health.

Hypothesis: Bone alterations-whether systemic or local-represent a risk factor for implant failure and peri-implantitis.

Objectives: To analyze implant failure and marginal bone loss in patients with local and/or systemic bone alterations compared to patients without such conditions.

Methods: Implant failures occurring in patients treated within the Master's Program in Oral Medicine, Surgery, and Implantology at the University of Barcelona (MCIO-UB) over the last 10 years will be analyzed and correlated with bone factors (local and systemic) recorded in their medical histories. Cases lacking the radiographic and clinical data necessary to conduct the study will be excluded.

Population: A total of 3,500 implants have been placed, with failure rates ranging from 4% to 8% depending on the techniques used; consequently, the study sample will consist of 192 implants. Cohorts of successful implants will be established by matching patients of the same sex and within a ±5-year age range who did not experience implant failure.

Conditions

  • Peri Implant Mucositis
  • Peri Implant Bone Loss
  • Peri Implantitis
  • Calcium Deficiency
  • Phosphorus and Calcium Disorders
  • Vitamin D Deficiency
  • Renal Insufficiency / Therapy
  • Renal Insufficiency Chronic
  • Renal Insufficiency, Acute
  • Renal Insuficiency
  • Prothesis
  • Prosthesis and Implants
  • Diabetes (DM)
  • Kidney Disease

Sponsors & Collaborators

  • University of Barcelona

    lead OTHER

Principal Investigators

  • José López López, University Professor · University of Barcelona

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-10-15
Completion
2027-02-15

Countries

  • Spain

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07766707 on ClinicalTrials.gov