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Investigating Modulation of Neuropathic Pain by Transcranial Magnetic Stimulation: a Multimodal Imaging and Electrophysiological Approach

NCT07758348 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2026-08-11

No results posted yet for this study

Summary

The proposed project will combine functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to identify neurobiological mechanisms underlying how repetitive transcranial magnetic stimulation (rTMS) applied to the primary motor cortex modulates maladaptive neuroplasticity following neuropathic pain.

Conditions

  • Patients With Neuropathic Pain Due to Peripheral Neuropathy

Interventions

DEVICE

repetitive TMS

30 trains of TMS pulses delivered at 10 Hz for 10 s (100 pulses/train) with a 20-s intertrain interval, leading to 3000 pulses per session for a total duration of 15 min

DEVICE

sham stimulation

the stimulation coil will be tilted 90 degrees away from the scalp. This orientation ensures that the participant experiences the characteristic clicking sound and physical sensation of the TMS machine without the magnetic field reaching the brain.

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Principal Investigators

  • Chi-Chao Chao, MD. PhD · National Taiwan University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-30
Primary Completion
2030-07-31
Completion
2030-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07758348 on ClinicalTrials.gov