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Feasibility and Effects of Noninvasive Brain Stimulation on Pain Perception in People With Fibromyalgia

NCT07644221 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-06-12

No results posted yet for this study

Summary

The goal of this interventional study is to learn whether noninvasive brain stimulation (NIBS) will have an effect on pain perception in people with fibromyalgia. The main questions it aims to answer are:

Do repeated sessions of NIBS lead to a reduction in perceived pain? Do repeated sessions of NIBS lead to an improvement in quality of life?

Researchers will compare different brain targets to see if effects are different between them.

Participants will receive repeated daily sessions of NIBS over 4 weeks with application of pressure pain algometry, and complete various questionnaires.

Conditions

  • Fibromyalgia (FM)

Interventions

DEVICE

Occipital Lobe Stimulation

Short (\<1 ms), high amplitude (\>10 mA) noninvasive electrical pulses delivered at 1 Hz on the scalp surface. This intervention will target the occipital lobe.

DEVICE

Primary Motor Cortex Stimulation

Short (\<1 ms), high amplitude (\>10 mA) noninvasive electrical pulses delivered at 1 Hz on the scalp surface. This intervention will target the primary motor cortex (M1).

Sponsors & Collaborators

  • Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh

    collaborator UNKNOWN

  • University of Pittsburgh Clinical and Translational Science Institute (CTSI)

    collaborator UNKNOWN

  • Pulkit Grover

    lead OTHER

Principal Investigators

  • Pulkit Grover, PhD · Carnegie Mellon University

  • Benedict J Alter, MD, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2027-05-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07644221 on ClinicalTrials.gov