MedTrace Logo

Exploration of Brain Functional Networks in Patients With Hidradenitis Suppurativa Using fMRI

NCT07755670 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-08-10

No results posted yet for this study

Summary

The goal of this observational study is to learn whether adults with hidradenitis suppurativa (HS) have changes in resting brain activity and how these changes are related to disease severity, pain, sleep, mood, and quality of life. The study will also examine whether brain activity changes after patients receive biologic or small-molecule treatment as part of their regular medical care.

The main questions it aims to answer are:

* Are resting brain activity patterns different between people with HS and healthy participants?
* Are these brain activity patterns related to HS severity, pain, sleep problems, anxiety, depression, and quality of life?
* Do brain activity patterns change after 3 months of routine treatment, and are these changes related to improvement in HS symptoms? Researchers will compare participants with HS with healthy participants of similar age and sex. A subgroup of participants with HS who receive biologic or small-molecule treatment as part of routine clinical care will also be assessed before and after treatment.

Participants may:

* Complete assessments of HS severity, pain, sleep, mood, and quality of life
* Undergo resting-state functional magnetic resonance imaging
* Undergo skin ultrasound and routine laboratory testing
* Allow photographs of affected skin areas to be taken
* Return for follow-up assessments for up to 3 months

Conditions

  • Hidradenitis Suppurativa (HS)

Interventions

BIOLOGICAL

Routine Biologic Therapy for Hidradenitis Suppurativa

Biologic therapy is prescribed by the treating physician as part of routine clinical care and is not assigned by the study protocol. The study observes changes in clinical outcomes and resting-state brain activity before treatment and during 3 months of follow-up.

Sponsors & Collaborators

  • Second Xiangya Hospital of Central South University

    lead OTHER

Principal Investigators

  • Yi Zhan · Second Xiangya Hospital of Central South University

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-03
Primary Completion
2027-01-31
Completion
2027-01-31

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07755670 on ClinicalTrials.gov