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Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion

NCT07754942 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-08-10

No results posted yet for this study

Summary

The goal of this observational study is to describe the local change in interleukin-6 (IL-6) across a blood clot in adults with acute ischemic stroke caused by anterior circulation large vessel occlusion who are undergoing mechanical thrombectomy.

The main questions it aims to answer are:

* Is the level of IL-6 different in arterial blood collected beyond the clot compared with arterial blood collected before the clot during mechanical thrombectomy?
* Is the trans-thrombus IL-6 difference associated with functional independence 90 days after stroke and with complications related to reperfusion injury? There is no comparison group and no experimental treatment. Researchers will compare paired blood samples collected from opposite sides of the clot in the same participant. Blood collected from a peripheral vein at hospital admission will be used only as a supportive reference for systemic inflammation.

Participants will:

* Receive standard mechanical thrombectomy and stroke care determined by their treating clinical team.
* Have small blood samples collected at planned time points, including paired arterial blood samples collected during the thrombectomy procedure.
* Have clinical and imaging information collected from their medical records and have functional status assessed 90 days after stroke.

The study will not delay or change standard stroke treatment.

Conditions

  • Acute Ischemic Stroke
  • Large Vessel Occlusion

Interventions

OTHER

Prospective Mechanical Thrombectomy Cohort

Adults with acute ischemic stroke due to anterior circulation large vessel occlusion who undergo clinically indicated mechanical thrombectomy. All participants receive standard stroke care determined by the treating clinical team; no experimental intervention is assigned. Paired arterial blood samples are collected during thrombectomy from sites proximal and distal to the thrombus. A peripheral venous blood sample collected at hospital admission is used as a supportive systemic reference. Clinical, imaging, procedural, and 90-day functional outcome data are collected prospectively.

Sponsors & Collaborators

  • Zhongshan Hospital Xiamen University

    lead OTHER

Principal Investigators

  • Xingyu Chen, MD · Zhongshan Hospital Xiamen University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2028-08-01
Completion
2029-08-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07754942 on ClinicalTrials.gov