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Comprehensive Clinical Prediction Rule for Acute Heart Failure

NCT07754084 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 560

Last updated 2026-08-11

No results posted yet for this study

Summary

The goal of this prospective observational cohort study is to establish a comprehensive clinical prediction rule integrating clinical characteristics, point-of-care testing (POCT) of NT-proBNP, an 8-point LUS, and a rapid cardiac assessment using bedside echocardiography for diagnosing acute heart failure (AHF) in the emergency department. A clinical prediction rule with high diagnostic accuracy will minimize delays and misdiagnoses, as well as the potential harm they may cause to patients. The primary outcome measure is the adjudicated AHF diagnosis. Secondary outcome measures include ED and discharge diagnosis of the patients.

Conditions

  • Acute Heart Failure (AHF)

Interventions

DIAGNOSTIC_TEST

Acute Heart Failure Diagnostic Method

Beside echocardiography (to assess the LV function, IVC, pericardial effusion or cardiac tamponade). Blood tests including NT-proBNP for risk stratification. 8 point lung ultrasound to look for B-lines.

Sponsors & Collaborators

  • Prince of Wales Hospital, Shatin, Hong Kong

    collaborator OTHER

  • The University of Hong Kong

    collaborator OTHER

  • Tuen Mun Hospital, Hospital Authority, Hong Koong

    collaborator UNKNOWN

  • Queen Mary Hospital, Hong Kong

    collaborator OTHER

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • Kevin KC Hung, Dr. · Chinese University of Hong Kong

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-17
Primary Completion
2028-12-31
Completion
2029-01-31

Countries

  • Hong Kong

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07754084 on ClinicalTrials.gov