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Figuring Out the Genetic Mutations That Lead to Lower Jaw Advancement More Than the Upper Jaw

NCT07749638 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 93

Last updated 2026-08-06

No results posted yet for this study

Summary

Purpose of the Research:

To reveal the genetic cause for the occurrence of Class III malocclusion, or what may be described as a reverse bite (underbite).

Introduction and Detailed Procedures for the Patient (Work Plan):

1. The volunteer will rinse their mouth with chlorhexidine before taking the swab.
2. A saliva sample will be collected from the patient using a syringe, along with a frontal facial photograph and a lateral cephalometric X-ray.
3. DNA / genetic material will be extracted from the sample.
4. Screening will be conducted for genetic mutations that may be responsible for the occurrence of the underbite.
5. The photographs and X-rays will be analyzed and compared with the swab results.
6. This data will be analyzed to determine whether the detected mutations are the cause of the underbite.
7. The sample will be retained for use in future research studies.

Side Effects, Expected Risk Levels, and Management"

* Pain: Mild discomfort during swab collection, which does not require any painkillers.
* Infection/Inflammation: Mild inflammation at the sample site or a secondary bacterial infection; in this case, antibiotics may be prescribed if necessary.
* Risk Level: Low risk, estimated to be less than 5%.

Conditions

  • Skeletal Class III Malocclusion

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Eligibility

Min Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2026-02-05
Completion
2026-07-09

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07749638 on ClinicalTrials.gov