Study of Neoadjuvant RBP-01 In Patients With Primary Uveal Melanoma
NCT07747935 · Status: NOT_YET_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2026-08-05
Summary
Neoadjuvant RBP-01 in patients with primary uveal melanoma.
Conditions
Interventions
- DRUG
-
RBP-01
Each RBP-01 dose consists of a 5 µL intravitreal injection conjugating 250 µg of sotrastaurin.
Sponsors & Collaborators
-
ReBio Pharma
lead INDUSTRY
Principal Investigators
-
Ido Didi Fabian, Prof. · Sheba Medical Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-10-01
- Primary Completion
- 2028-04-01
- Completion
- 2028-04-01
More Related Trials
-
Neoadjuvant Darovasertib in Primary Uveal Melanoma
NCT07015190 ·Status: RECRUITING ·Phase: PHASE3
-
A Phase II Study of BVD-523 in Metastatic Uveal Melanoma
NCT03417739 ·Status: TERMINATED ·Phase: PHASE2
-
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
NCT06581406 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Phase I Safety and Dosimetry Study in Patients With Confirmed Metastatic Melanoma
NCT00747825 ·Status: TERMINATED ·Phase: PHASE1
-
(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma
NCT05907954 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma
NCT04935229 ·Status: TERMINATED ·Phase: PHASE1
-
Nivolumab Plus Relatlimab in Patients With Metastatic Uveal Melanoma
NCT04552223 ·Status: COMPLETED ·Phase: PHASE2
-
Intermittent Selumetinib for Uveal Melanoma
NCT02768766 ·Status: COMPLETED ·Phase: PHASE1
-
Adjuvant Tebentafusp in High Risk Ocular Melanoma
NCT06246149 ·Status: RECRUITING ·Phase: PHASE3
-
Trametinib With or Without GSK2141795 in Treating Patients With Metastatic Uveal Melanoma
NCT01979523 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Intratumoral CAVATAK (CVA21) and Ipilimumab in Patients With Advanced Melanoma (VLA-013 MITCI)
NCT02307149 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy in Treating Patients With Melanoma of the Eye
NCT00036816 ·Status: TERMINATED ·Phase: PHASE3
-
Pembrolizumab in Treating Patients With Advanced Uveal Melanoma
NCT02359851 ·Status: TERMINATED ·Phase: PHASE2
-
IKKb-matured, RNA-loaded Dendritic Cells for Metastasised Uveal Melanoma
NCT04335890 ·Status: COMPLETED ·Phase: PHASE1
-
Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma
NCT03743298 ·Status: RECRUITING ·Phase: PHASE1
-
Lenalidomide (Revlimid) to Treat Advanced Ocular Melanoma
NCT00109005 ·Status: COMPLETED ·Phase: PHASE2
-
Ranibizumab in Combination With Proton Beam Irradiation for Choroidal Melanoma
NCT00765921 ·Status: COMPLETED ·Phase: PHASE1
-
Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma
NCT05524935 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular Melanoma
NCT01814046 ·Status: TERMINATED ·Phase: PHASE2
-
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
NCT03767348 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Targeted Alpha Particle Radiotherapy for Metastatic Uveal Melanoma
NCT05496686 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
NCT05987332 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
Pembrolizumab With Talimogene Laherparepvec or Placebo in Unresected Melanoma
NCT02263508 ·Status: TERMINATED ·Phase: PHASE3
-
Melanoma Inhibitory Activity (MIA): A Serological Marker for Metastatic Uveal Melanoma
NCT00406900 ·Status: UNKNOWN
-
Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma
NCT06627244 ·Status: RECRUITING ·Phase: PHASE2