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Povidone Iodine for Caries Prevention

NCT07741409 · Status: NOT_YET_RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 174

Last updated 2026-08-03

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to answer are:

1. How will home use of Povidone Iodine, as an adjunct treatment to standard dental care, reduce the incidence of tooth decay?
2. How will home use of Povidone Iodine reduce the mouth germs responsible for tooth decay?
3. If Povidone Iodine use is accompanied by probiotic use, will its effectiveness be even better than Povidone Iodine alone?

Participants will:

1. Provide a plaque sample at the beginning of the study.
2. Swab their children's teeth once a week for one month and then monthly thereafter. Some participants may be asked to use probiotic drops nightly after brushing their teeth.
3. Keep a record of compliance.
4. Return every 6 months for a dental exam and to provide a plaque sample. Keep a diary of their symptoms and the number of times they use a rescue inhaler

Conditions

  • Dental Caries

Interventions

DRUG

Povidone Iodine 5% Soln,Top,Kit

Home use of Povidone Iodine administered by swabbing teeth; weekly for the 1st month, monthly thereafter.

DIETARY_SUPPLEMENT

Probiotics

Home use of Povidone Iodine coupled with daily use of a probiotic.

DRUG

Placebo

Placebo for the Povidone Iodine

Sponsors & Collaborators

  • Jeffrey A. Banas

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
1 Year
Max Age
3 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-03
Primary Completion
2027-12-31
Completion
2028-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07741409 on ClinicalTrials.gov