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Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes

NCT07734740 · Status: NOT_YET_RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-08-03

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.

Conditions

  • Dermatochalasis of Upper Eyelid
  • Blepharoplasty

Interventions

DRUG

Sodium Bicarbonate (NaHCO3)

Lignocaine buffered with sodium bicarbonate

DRUG

Warmed lignocaine

Lignocaine warmed to body temperature

DRUG

Hyaluronidase Injection

Lignocaine with hyaluronidase added

DRUG

Tranexamic Acid (TXA)

Lignocaine with tranexamic acid added

DRUG

Lignocaine 2% concentration solution

2% lignocaine with 1:200,000 adrenaline

Sponsors & Collaborators

  • Chinese University of Hong Kong

    collaborator OTHER

  • Prince of Wales Hospital, Shatin, Hong Kong

    lead OTHER

Principal Investigators

  • Kelvin Kam Lung Chong · Prince of Wales Hospital, Shatin, Hong Kong

  • Anson Chun Long Wu · Prince of Wales Hospital, Shatin, Hong Kong

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2028-07-31
Completion
2028-07-31

Countries

  • Hong Kong

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07734740 on ClinicalTrials.gov