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The Effect of Nicorandil on Rheumatoid Arthritis Patients

NCT07730723 · Status: NOT_YET_RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-07-28

No results posted yet for this study

Summary

The aim of this clinical trial is to determine whether nicorandil works in minimizing disease severity in patients with rheumatoid arthritis. The study will also assess the safety and tolerability of nicorandil. The main questions it aims to answer are:

* Could nicorandil improve disease severity and symptoms of rheumatoid arthritis?
* Does nicorandil lower the number of times participants need to use pain relieve medications?
* Does the nicorandil improve participants functionality and ability to carry out daily activity?
* Does nicorandil correct disease-associated damage and inflammation?
* What side effects do participants have when taking nicorandil? Researchers will compare nicorandil to a placebo (a look-alike substance that contains no drug) to see if nicorandil works to decrease symptoms and severity of rheumatoid arthritis.

Participants will:

* Take nicorandil or a placebo two times daily for 3 months
* Visit the clinic once every month for checkups
* Keep a diary of their symptoms and the number of times they use a pain reliever

Conditions

  • Rheumatoid Arthritis (RA)

Interventions

DRUG

Nicorandil Oral Tablet

Nicorandil 10 mg oral tablets will be taken as one tablet twice daily for 3 months (12 weeks).

DRUG

Placebo

Placebo oral tablets will be taken as one tablet twice daily for 3 months (12 weeks).

DRUG

conventional synthetic antirheumatic drugs (cDMARDs)

A single or combination of cDMARDs and dose depend on disease severity.

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2027-07-31
Completion
2027-07-31

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07730723 on ClinicalTrials.gov