MedTrace Logo

Topical Oxygen Therapy for BRONJ

NCT07725107 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-07-24

No results posted yet for this study

Summary

A randomized clinical trial comparing Blue®m oral gel and autologous PRF membrane as adjuncts to surgical debridement in BRONJ/MRONJ patients.

Conditions

  • Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)
  • Oxygen
  • Topical Administration
  • Wound Healing

Interventions

PROCEDURE

Topical Blue®m application

Intraoperative application of Blue®m oral gel to the debrided surgical site before primary closure

PROCEDURE

PRF membrane placement

Intraoperative placement of an autologous PRF membrane over the debrided surgical site before flap closure.

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2026-08-31
Completion
2026-09-30

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07725107 on ClinicalTrials.gov