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Laser Therapy Versus Ozone Therapy for Oral Mucositis in Patients With Cancer

NCT07724444 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2026-07-24

No results posted yet for this study

Summary

This retrospective observational study will compare laser therapy and ozone therapy for the management of oral mucositis in adults with head and neck cancer. Oral mucositis is a painful inflammation of the mouth that may develop during radiotherapy, chemotherapy, or concurrent chemoradiotherapy and can cause redness, ulceration, difficulty eating or swallowing, and reduced quality of life.

The study will review existing clinical records of patients who previously received either laser therapy or ozone therapy as part of routine clinical care. Patients were not assigned to treatment by the study protocol, and no additional treatment or study procedures will be performed.

The main outcome will be the change in oral mucositis severity measured using the World Health Organization oral mucositis scale. Secondary outcomes will include changes in oral pain measured using a visual analogue scale and changes in oral mucositis-related quality of life, when questionnaire data are available.

The aim is to determine whether the clinical course of oral mucositis differs between patients treated with laser therapy and those treated with ozone therapy.

Conditions

  • Oral Mucositis

Interventions

DEVICE

Laser Therapy

Adult patients in this cohort previously received diode laser therapy for oral mucositis as part of routine clinical care. Treatment was delivered to the affected oral mucosa using a diode laser device. Available medical records will be reviewed to retrieve treatment parameters, including wavelength, power, energy, application time, number of treated sites, treatment frequency, and number of sessions, when documented. No laser treatment will be assigned or administered as part of this retrospective study.

DEVICE

Ozone therapy

Adult patients in this cohort previously received topical gaseous ozone therapy for oral mucositis as part of routine clinical care. Ozone was applied to the affected oral mucosa using an intraoral ozone-generating device and a dedicated probe. Available medical records will be reviewed to retrieve treatment parameters, including device settings, application duration, treated sites, treatment frequency, and number of sessions, when documented. No ozone treatment will be assigned or administered as part of this retrospective study.

Sponsors & Collaborators

  • University of Pavia

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-25
Primary Completion
2025-09-15
Completion
2025-09-29

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07724444 on ClinicalTrials.gov