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Impact of Exercise on Muscle Metabolism and Function for Persons With Parkinsons

NCT07720713 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2026-07-22

No results posted yet for this study

Summary

This investigation assesses the impact of a strengthening program on muscle metabolism in the gastrocnemius muscle (GM) and is an essential step in the establishment of future clinical intervention for the GM in people with Parkinson's disease (with healthy peers as the control group). The participants will be provided with a progressive GM strengthening program while monitoring muscle metabolism and functional changes before and after intervention.

Conditions

  • Parkinson

Interventions

OTHER

Home Exercise Program

All participants completed a four-week, home-based progressive strengthening program targeting GM using high-volume bodyweight exercise. Participants were instructed to perform exercises three times per week, with at least one day of rest between exercise sessions. During weeks 1 and 2, participants performed two sets of heel raises to fatigue at their prescribed level, corresponding to a subjective effort rating of 8/10. The goal was to progress toward completing 20 repetitions per set. Exercise loading was individualized based on baseline performance and adjusted throughout the intervention according to each participant's demonstrated strength progression.

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
50 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-04-27
Primary Completion
2023-06-30
Completion
2023-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07720713 on ClinicalTrials.gov