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HME Amino Acid Supplementation for Strength, Performance, and Recovery in Trained Adult Males

NCT07715201 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-07-23

No results posted yet for this study

Summary

This pilot randomized controlled trial evaluates HME (Human Muscle Equivalent), a free-form amino acid supplement formulated to match the amino acid composition of human skeletal muscle, taken at its Health Canada licensed dose (3 g powder plus one 50 mg slow-release beta-alanine capsule daily). Trained adult males (competitive athletes or certified fitness professionals) are randomized to HME or an identical-appearing placebo for 10 weeks: a 2-week supplement-only lead-in followed by 8 weeks of supplement plus supervised resistance training. The primary aim is to estimate the effect of HME on composite maximal strength (1-repetition maximum leg press plus chest press) compared with placebo. Secondary measures include isometric knee-extension strength, countermovement jump height, and subjective recovery.

Conditions

  • Muscle Strength
  • Athletic Performance
  • Resistance Training

Interventions

DIETARY_SUPPLEMENT

HME (Human Muscle Equivalent)

HME (Human Muscle Equivalent) is a two-component amino acid formulation taken together as a single daily serving: a 3 g free-form amino acid powder matched to the human skeletal muscle amino acid profile, plus a slow-release capsule containing 50 mg beta-alanine. Both components together constitute HME. Health Canada NPN 80148183 (powder) and 80148185 (capsule).

DIETARY_SUPPLEMENT

Placebo

Maltodextrin powder and capsule matched for appearance, volume, and taste.

Sponsors & Collaborators

  • Orivian inc

    lead INDUSTRY

Principal Investigators

  • Reza Ardekani, MD PhD · Orivian inc

  • Anthony Galea, MD · The Institute of Human Mechanics

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-29
Primary Completion
2026-12-29
Completion
2027-03-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07715201 on ClinicalTrials.gov