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Triamcinolone Nanocapsules After Endoscopic Nasal Surgery

NCT07714525 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-07-27

No results posted yet for this study

Summary

This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery.

Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.

Conditions

  • Chronic Rhinosinusitis (CRS)
  • Nasal Polyps
  • Postoperative Healing After Endoscopic Nasal Surgery

Interventions

DRUG

Triamcinolone Acetonide-Loaded Polymeric Nanocapsules

Triamcinolone acetonide incorporated into polymeric nanocapsules prepared using a nanoprecipitation method will be administered topically to the postoperative nasal cavity.

OTHER

Normal Saline Nasal Irrigation

Participants will receive postoperative nasal irrigation with 0.9% sodium chloride solution.

Sponsors & Collaborators

  • Deraya University

    lead OTHER

Principal Investigators

  • Sally Mansour Helmy · Deraya University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2027-05-01
Completion
2027-06-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07714525 on ClinicalTrials.gov