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Serial Diaphragm Ultrasound Evaluation During Inspiratory Muscle Training in Prolonged Mechanical Ventilation

NCT07709793 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-07-17

No results posted yet for this study

Summary

Diaphragm dysfunction contributes to prolonged mechanical ventilation (PMV) and difficult weaning. Inspiratory muscle training (IMT) may improve respiratory muscle performance, while serial diaphragm ultrasound offers a bedside method for monitoring diaphragmatic recovery. This study used diaphragm ultrasound to evaluate the effects of high- versus low-intensity IMT in patients with PMV and diaphragm dysfunction.

In this prospective study, patients received high- or low-intensity IMT for up to 2 weeks or until ventilator liberation. Respiratory mechanics, including respiratory rate, tidal volume, minute ventilation, rapid shallow breathing index, and maximal inspiratory pressure, were assessed twice weekly. Diaphragm excursion and thickening fraction were also measured serially after IMT initiation. Changes in respiratory physiological parameters and diaphragm ultrasound measurements were compared between the two IMT groups, and differences in ventilator liberation outcomes were evaluated.

Conditions

  • Prolonged Mechanical Ventilation

Interventions

PROCEDURE

High intensity IMT

high intensity IMT: high intensity training

PROCEDURE

Low intensity IMT

low intensity IMT: low intensity training

Sponsors & Collaborators

  • Chang Gung Memorial Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-09
Primary Completion
2025-05-27
Completion
2025-06-30

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07709793 on ClinicalTrials.gov