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Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis

NCT07707609 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-07-16

No results posted yet for this study

Summary

Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology. Increasing evidence suggests that persistent pain is not solely driven by peripheral pancreatic abnormalities but also by central sensitization, involving maladaptive changes in central nervous system pain-processing pathways. While altered brain connectivity and neurochemical changes have been demonstrated in other chronic pain disorders, these mechanisms remain poorly characterized in CP.

This study aims to integrate clinical phenotyping with blood-based metabolite profiling and advanced neuroimaging, including resting-state functional MRI and magnetic resonance spectroscopy, to investigate the relationship between central sensitization, brain dysfunction, and neuropsychological alterations. The findings may identify objective neurobiological markers of pain and facilitate the development of mechanism-based, personalized treatment strategies for patients with chronic pancreatitis.

Conditions

  • Chronic Pancreatitis
  • Pain Management

Interventions

DIAGNOSTIC_TEST

Comprehensive Neuropsychological Assessment

A comprehensive set of clinical and neurological tests to be performed on all participants. This includes validated mental state and sleep evaluations (HADS, PSQI), quality-of-life assessments (EORTC QLQ-C30 + PAN28),and quantitative sensory testing (P-QST)

DIAGNOSTIC_TEST

Resting-State Functional MRI (fMRI)

An advanced neuroimaging scan performed on all participants to assess resting-state functional connectivity within key pain-processing networks.

DIAGNOSTIC_TEST

Magnetic Resonance Spectroscopy (MRS)

A neuroimaging technique performed on all participants to quantify brain metabolites in key brain regions.

DIAGNOSTIC_TEST

Blood-Based Metabolite Profiling

Blood samples will be collected from all participants to quantify metabolomic signatures and to identify potential correlates with pain phenotypes in chronic pancreatitis.

Sponsors & Collaborators

  • Asian Institute of Gastroenterology, India

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-06
Primary Completion
2026-11-06
Completion
2026-11-30

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07707609 on ClinicalTrials.gov