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Heart Rate Variability and Medication Adherence in Resistant Hypertension

NCT07707583 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-07-16

No results posted yet for this study

Summary

This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in patients with resistant hypertension. Patients are recruited opportunistically, in a nurse-led manner, in a one-day-care cardiology unit, and undergo a single examination: a short-term HRV recording (Polar H10), a single blood draw for antihypertensive drug levels, office blood pressure, and self-completed questionnaires. There is no follow-up.

Conditions

Interventions

DIAGNOSTIC_TEST

Heart rate variability recording (Polar H10) ·

Short-term (10-15 min) seated HRV; time-domain (SDNN, RMSSD, pNN50) and frequency-domain (LF, HF, LF/HF) parameters.

DIAGNOSTIC_TEST

Therapeutic drug monitoring (antihypertensive drug levels)

Single blood draw measuring antihypertensive drug levels; defines adherent vs non-adherent status.

OTHER

Questionnaires (MARS-CZ, PHQ-9, SF-36, IPAQ)

Self-completed instruments assessing medication adherence, mood, quality of life, and physical activity.

Sponsors & Collaborators

  • Masaryk University

    collaborator OTHER

  • Nemocnice AGEL Trinec-Podlesi a.s.

    lead OTHER

Principal Investigators

  • Jan Alexander Mohr, MD · Nemocnice AGEL Třinec-Podlesí a.s.

  • Matej Pekar, MD, PhD · Nemocnice AGEL Třinec-Podlesí a.s.

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-20
Primary Completion
2027-07-20
Completion
2027-12-31

Countries

  • Czechia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07707583 on ClinicalTrials.gov