MedTrace Logo

The Role of Gut and Skin Microbiota in Alopecia Areata

NCT07705217 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-07-15

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if fecal microbiota transplantation (FMT) works to treat alopecia areata in adults. It will also learn about the safety of FMT. The main questions it aims to answer are:

* Can FMT cause hair regrowth?
* Can FMT modulate immune response? Researchers will compare FMT to a placebo (a look-alike substance that contains no drug) to see if FMT works to treat alopecia areata.

Participants will:

* Take FMT or a placebo for three consecutive days
* Follow-up evaluations will be performed at weeks 12, 24, and 48, with repeat clinical scoring, photodocumentation, microbiome analyses, laboratory testing, and quality-of-life assessment.

Conditions

  • Alopecia Areata
  • Fecal Microbiota Transplantation (FMT)
  • T Cell Subsets
  • Microbiome

Interventions

OTHER

Fecal Microbial Transplant Enema

Patients with alopecia areata will recieve FMT or in the 3 capsules for three consecutive days or FMT via colonoscopy

OTHER

Placebo

Patients will recieve three capsules with inert material or saline via colonoscopy

Sponsors & Collaborators

  • Polyclinic GrandMed

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-31
Primary Completion
2027-02-28
Completion
2027-10-31

Countries

  • Croatia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07705217 on ClinicalTrials.gov