Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants
NCT02812342 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2019-01-30
Summary
The purpose of the study is to investigate the use of topical tofacitinib to promote hair regrowth in patients with alopecia areata, alopecia totalis, and alopecia universalis.
Conditions
- Alopecia Areata
- Alopecia Totalis
- Alopecia Universalis
Interventions
- DRUG
-
Tofacitinib ointment
Patients with AA (with at least 2 patches of alopecia involving the scalp), AT or AU will be treated with tofacitinib ointment for a maximum of 6 months. During treatment, patients will be evaluated every 4 weeks and effectiveness of the medication will be measured by changes in hair growth.
Sponsors & Collaborators
-
Yale University
lead OTHER
Principal Investigators
-
Brett King, MD, PhD · Yale University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-09-30
- Primary Completion
- 2018-07-31
- Completion
- 2018-12-31
Countries
- United States
Study Locations
More Related Trials
-
Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia Areata
NCT02684123 ·Status: COMPLETED ·Phase: NA
-
A Study With Ruxolitinib Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA)
NCT02553330 ·Status: TERMINATED ·Phase: PHASE2
-
A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Alopecia Areata
NCT05556265 ·Status: TERMINATED ·Phase: PHASE2
-
Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/Universalis
NCT01314495 ·Status: WITHDRAWN ·Phase: PHASE2
-
Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD)
NCT03359356 ·Status: COMPLETED ·Phase: PHASE2
-
Effectiveness and Safety of Tofacitinib in Patients With Recalcitrant Frontal Fibrosing Alopecia : A Pilot Study
NCT06202560 ·Status: COMPLETED ·Phase: NA
-
An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia Areata
NCT02018042 ·Status: COMPLETED ·Phase: PHASE2
-
Local Pharmacokinetics and Tolerability of Bimatoprost Applied to the Scalp of Male Patients With Androgenetic Alopecia
NCT02848300 ·Status: COMPLETED ·Phase: PHASE1
-
LEO 124249 Ointment in the Treatment of Alopecia Areata
NCT02561585 ·Status: COMPLETED ·Phase: PHASE2
-
ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT)
NCT03759340 ·Status: TERMINATED ·Phase: PHASE2
-
Safety and Pharmacokinetic Study of ATI-50002 in Subjects With Alopecia Universalis (AU) and Alopecia Totalis (AT)
NCT03315689 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial to Evaluate the Efficacy of Fecal Microbiota Transplantation in Patients With Alopecia Areata
NCT04238091 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Clinical Trial to Evaluate the Efficacy of Abatacept in Moderate to Severe Alopecia Areata
NCT01917058 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study of Secukinumab for the Treatment of Alopecia Areata
NCT02599129 ·Status: TERMINATED ·Phase: PHASE2
-
Rhofanib® (Tofacitinib) Safety and Effectiveness Evaluation
NCT07101471 ·Status: COMPLETED
-
A Study in Male and Female Subjects With Androgenetic Alopecia Treated With ATI-50002 Topical Solution
NCT03495817 ·Status: COMPLETED ·Phase: PHASE2
-
ATI-501 Oral Suspension Compared to Placebo in Subjects With Alopecia Areata, Alopecia Universalis or Alopecia Totalis
NCT03594227 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Application of Stem Cell Educator Therapy in Alopecia Areata
NCT04011748 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy and Tolerability Study of Two Dosing Regimens of CTP-543 in Adults With Alopecia Areata
NCT03941548 ·Status: COMPLETED ·Phase: PHASE2
-
Pilot Study to Evaluate the Efficacy of Ruxolitinib in Alopecia Areata
NCT01950780 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Tolerability Study of Two Dose Regimens of CTP-543 in Adults With Alopecia Areata
NCT03811912 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial of Safety and Efficacy of Daily Application of Topical Dutasteride in Men With Androgenic Alopecia.
NCT05599243 ·Status: COMPLETED ·Phase: PHASE2
-
Alefacept in Patients With Severe Scalp Alopecia Areata
NCT00167102 ·Status: COMPLETED ·Phase: NA
-
Efficacy and Safety of Oral Tofacitinib in the Treatment of Alopecia Areata
NCT06157905 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata
NCT05398809 ·Status: RECRUITING ·Phase: PHASE2