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Low-Dose Radiotherapy for Alzheimer's Disease

NCT07693140 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-07-09

No results posted yet for this study

Summary

To evaluate the safety and tolerability of low-dose whole brain radiotherapy (WBRT) delivered as an induction course of 0.3 Gy × 10 fractions (3.0 Gy total) followed by 12 months of monthly maintenance LDRT (0.3 Gy × 10 fractions; 3.0 Gy total) in patients with Alzheimer's disease or dementia with inflammatory components

Conditions

  • Alzheimer Dementia
  • Dementia
  • Alzheimer Dementia (AD)
  • Alzheimer
  • Alzheimer s Disease

Interventions

RADIATION

Low Dose Radiation Therapy

Low dose whole brain radiotherapy delivered as an induction course of 10 fractions followed by 12 months of monthly maintenance LDRT in 10 fractions starting 2 months post-induction

Sponsors & Collaborators

  • Evan Thomas

    lead OTHER

Principal Investigators

  • Evan Thomas, MD, PhD · Renaissance Institute of Precision Oncology and Radiosurgery

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-15
Primary Completion
2029-05-21
Completion
2029-05-21

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07693140 on ClinicalTrials.gov