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ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up

NCT07680855 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 17

Last updated 2026-07-02

No results posted yet for this study

Summary

The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.

The main questions it aims to answer are:

1. Do inflammatory cytokine levels change after anthracycline chemotherapy and remain altered many years after treatment?
2. Are long-term markers of oxidative stress and antioxidant capacity associated with changes in heart structure or function after anthracycline exposure?

This study does not include a comparison group. All participants were previously treated with anthracycline-based chemotherapy as part of their standard cancer care.

Participants will:

1. Provide blood samples for the measurement of inflammatory cytokines and oxidative stress-related biomarkers
2. Undergo a clinical cardiovascular evaluation
3. Receive a transthoracic echocardiogram to assess heart function, including measures of systolic and diastolic function and myocardial deformation
4. Participate in a long-term follow-up assessment approximately 10 years after their initial cancer treatment

Conditions

Sponsors & Collaborators

  • University of Chile

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-02-01
Primary Completion
2026-04-30
Completion
2026-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07680855 on ClinicalTrials.gov