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Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus

NCT07680010 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 105

Last updated 2026-07-17

No results posted yet for this study

Summary

Immunologic thrombocytopenic purpura (ITP) in children is a pre-lupus condition if associated with the presence of anti-nuclear antibodies (ANA), providing a unique model for understanding the natural history of autoimmunity, particularly that of systemic lupus erythematosus (SLE). The investigators will describe the shared and/or unique immunological pathways involved at diagnosis in 70 children with ITP and in 20 children with SLE, and compare them between ITP-ANA- (more often transient), ITP-ANA+ (pre-lupus condition, more often persistent) and SLE

Conditions

  • Immune Thrombocytopenic Purpura ( ITP )
  • Systemic Lupus Erythematosus (SLE)

Interventions

PROCEDURE

Blood sampling baseline and M3

Blood sampling is a routine biological procedure performed under the same conditions as during a follow-up consultation.

OTHER

Monitoring for SLE

Monitoring for Systemic Lupus Erythematosus according to SLICC 2012 classification criteria

PROCEDURE

Procedure/Surgery: Blood sampling baseline and M3 then each 6 months until 48 months

Blood sampling is a routine biological procedure performed under the same conditions as during a follow-up consultation.

OTHER

moniktoring for SLE : baseline and M3 then each 6 months until 48 months

Monitoring for Systemic Lupus Erythematosus according to SLICC 2012 classification criteria

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Jérôme GRANEL, MD · University Hospital, Bordeaux

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Year
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-07-31
Primary Completion
2029-10-31
Completion
2033-10-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07680010 on ClinicalTrials.gov