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Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial

NCT07671963 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-06-26

No results posted yet for this study

Summary

This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with the Non-Incised Papilla Surgical Approach (NIPSA) for the treatment of intrabony periodontal defects. The study will evaluate whether differences exist between the two biomaterials with respect to clinical attachment gain, defect resolution, wound healing and biological markers of regeneration.

Conditions

  • Periodontitis (Stage 3)
  • Minimally Invasive Surgical Procedures
  • Bone Substitutes

Interventions

PROCEDURE

GTO® with NIPSA surgical approach

Regenerative periodontal surgical treatment using the Non-Incised Papilla Surgical Approach (NIPSA) combined with GTO® collagenated xenogeneic bone substitute for the treatment of intrabony periodontal defects.

PROCEDURE

GenOs® + NIPSA

Regenerative periodontal surgical treatment using the Non-Incised Papilla Surgical Approach (NIPSA) combined with GenOs® collagenated xenogeneic bone substitute for the treatment of intrabony periodontal defects.

Sponsors & Collaborators

  • Cittadella Universitaria

    collaborator OTHER

  • University of Belgrade

    lead OTHER

Principal Investigators

  • Iva Z Milinkovic, DDS, PhD · School of Dental Medicine, University of Belgrade, Implant Research Centre and Department of Periodontology and Oral Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2027-02-01
Completion
2027-03-01

Countries

  • Italy
  • Serbia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07671963 on ClinicalTrials.gov