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Combined Regulatory Effects of 40 Hz eTNS and Multisensory Stimulation on Brain Networks

NCT07668167 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-07-01

No results posted yet for this study

Summary

The purpose of this study is to investigate the independent and interactive effects of 40Hz auditory, visual, and external trigeminal nerve stimulation (eTNS) on brain state dynamics and functional connectivity. While 40Hz visual and auditory sensory stimulation have been explored for potential cognitive and therapeutic benefits, the underlying mechanisms on large-scale brain networks and the potential effects of combining multiple modalities remain unclear.

This study aims to determine whether multimodal co-stimulation genuinely compounds network-level effects or if targeted dual-pairings are more efficient for brain network reorganization. In this within-subject study, 23 participants will receive all eight possible combinations of 40Hz auditory, visual, and eTNS (targeting the maxillary branch) in a randomized order. Each stimulation condition will last for 5 minutes, separated by 1-minute inter-stimulus intervals. Continuous electroencephalography (EEG) will be recorded throughout the procedures to evaluate brain responses. The collected EEG data will be analyzed using microstate analysis, functional connectivity analysis, and graph-theoretic network analysis. Ultimately, the study seeks to understand how these non-invasive stimulation techniques, independently and together, drive large-scale network reorganization and optimize the balance between local specialization and global integration in the brain.

Conditions

  • Healthy Participants

Interventions

DEVICE

40 Hz External Trigeminal Nerve Stimulation

Electrical stimulation targeting the maxillary branch of the trigeminal nerve at a frequency of 40 Hz

DEVICE

40 Hz Auditory Stimulation

Auditory sensory stimulation delivered at 40 Hz for 5-minute durations

DEVICE

40 Hz Visual Stimulation

Visual sensory stimulation delivered at a frequency of 40 Hz for 5-minute durations

OTHER

Sham Stimulation

Inactive control stimulation designed to mimic the sensory experience of the active modalities without delivering actual 40 Hz therapeutic stimulation

Sponsors & Collaborators

  • Xi'an Central Hospital

    collaborator OTHER

  • Xidian University

    lead OTHER

Principal Investigators

  • Xue-Juan Yang · Xidian University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-16
Primary Completion
2026-06-22
Completion
2026-06-23

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07668167 on ClinicalTrials.gov