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Remodelling of the Lower Airways in Chronic Cough

NCT07659860 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2026-06-22

No results posted yet for this study

Summary

The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month . Assessment of injury mediators will be performed in blood and bronchoalveolar lavage fluid. Remodelling features will be analysed based on chest CT scan and pathologic specimens. Injury of epithelium will be assessed in bronchial biopsy specimens. The relationship between the duration, severity of chronic cough, and bronchial inflammation, damage, remodelling will be analysed.

Conditions

  • Chronic Cough

Interventions

DIAGNOSTIC_TEST

chest computed tomography and bronchoscopy

Assessment of airway remodeling features on chest CT in patients with chronic cough. Evaluation of airway injury and remodeling based on biological specimens obtained from the lower airways during bronchoscopy.Bronchoscopy is performed if clinically indicated.

Sponsors & Collaborators

  • Medical University of Warsaw

    lead OTHER

Principal Investigators

  • Rafał Krenke, MD, PhD, Prof · Department of Internal Medicine, Pulmonary Diseases and Allergy, Warsaw Medical University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-01
Primary Completion
2026-07-30
Completion
2026-08-30

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07659860 on ClinicalTrials.gov