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The Efficacy of Vitamin D Supplementation to Sustain Performance Outcomes

NCT07654777 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2026-06-17

No results posted yet for this study

Summary

The goal of this clinical trial is to find out if vitamin D supplements help healthy adults maintain their cognitive and simple physical task performance and emotional state during highly stressful situations.

The main question it aims to answer is:

\- Does vitamin D help maintain cognitive and physical task performance and emotional state during highly stressful situations?

Researchers will compare vitamin D to placebo (a look-alike tablet that contains no active ingredients) to see if vitamin D better maintain cognitive and physical task performance and emotional state during highly stressful situations.

Participants will:

* Take vitamin D or placebo tablets daily for 8 weeks.
* Perform cognitive and simple physical tasks and rate their emotional state under highly stressful situations.
* Wear a stress belt that delivers mild electric shocks 1 - 5 times while participants are performing laboratory tasks.
* Wear a wristwatch-shaped activity monitor for 9 weeks.
* Visit the laboratory 5 times.

Conditions

  • Acute Stress Reaction

Interventions

DIETARY_SUPPLEMENT

Vitamin D3 (Cholecalciferol)

4,000 IU daily oral administration for 8 weeks.

DIETARY_SUPPLEMENT

Oral Placebo Tablet

Daily administration of two oral placebo tablets for 8 weeks

Sponsors & Collaborators

  • Walter Reed Army Institute of Research (WRAIR)

    lead FED

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2027-09-30
Completion
2027-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07654777 on ClinicalTrials.gov