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Impacts of HIV Treatment Regimens on Archived Drug Resistance

NCT07643948 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 420

Last updated 2026-06-12

No results posted yet for this study

Summary

The study aims to determine the prevalence of drug resistance mutation (DRM) in virally suppressed HIV infection, and the impacts of regimen change and the presence of low level viremia. Adults living with HIV infection on antiretroviral therapy (ART) with full viral suppression would be recruited. Cases are patients planning for regimen switch, while controls are those with and without low level viraemia (LLV) not planned for switch. Blood samples would be collected before and after switch. Sequencing would be performed to identify DRM present in HIV-1 proviral DNA.

Conditions

  • HIV -1 Infection
  • Antiretroviral Therapy
  • Drug Resistance, Microbial

Sponsors & Collaborators

  • Chinese University of Hong Kong

    lead OTHER

Principal Investigators

  • Shui Shan Lee, MD · S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong kong

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2029-09-30
Completion
2029-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07643948 on ClinicalTrials.gov