A Study of Cadonilimab Combined With Chemotherapy in People With Gastric or Gastroesophageal Junction Cancer
NCT07631000 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 37
Last updated 2026-06-05
Summary
The purpose of this study is to find out whether adding cadonilimab to the usual chemotherapy approach is an effective and safe treatment for participants with locally advanced/resectable gastric cancer or gastroesophageal junction (GEJ) cancer
Conditions
- Gastric Cancer
- Gastroesophageal-junction Cancer
Interventions
- DRUG
-
Perioperative cadonilimab plus neoadjuvant chemotherapy
Sponsors & Collaborators
-
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Yelena Janjigian, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-05-27
- Primary Completion
- 2029-05-27
- Completion
- 2029-05-27
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
An Investigational Study of Immunotherapy Combinations With Chemotherapy in Patients With Gastric or Gastroesophageal Junction (GEJ) Cancers
NCT03662659 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma
NCT07529808 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer
NCT06251973 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
NCT06901531 ·Status: RECRUITING ·Phase: PHASE3
-
Study of The Second-line Treatment of Advanced Gastric / Gastroesophageal Junction Adenocarcinoma With Cadonilimab and Fruquintinib Combined With Paclitaxel-albumin
NCT06406426 ·Status: RECRUITING ·Phase: PHASE2
-
Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
NCT05960955 ·Status: RECRUITING ·Phase: PHASE2
-
To Evaluate the Efficacy and Safety of Cadonilimab With SOX as Neoadjuvant Therapy for Resectable Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma.
NCT05948449 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of FMT Combined With Nivolumab in Gastric Cancer
NCT05001360 ·Status: WITHDRAWN ·Phase: NA
-
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
NCT05702229 ·Status: RECRUITING ·Phase: PHASE2
-
Phase Ib/IIa Open-label Study, to Evaluate Safety, Tolerability, and Antitumor Activity of HCB101 in Combination With Multiple Agents in Subjects With Advanced Gastric or Gastro-esophageal (GEJ) Adenocarcinoma
NCT07680569 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma
NCT00515411 ·Status: COMPLETED ·Phase: PHASE2
-
Early Access Program for Zolbetuximab
NCT06048081 ·Status: AVAILABLE
-
Cetuximab, Cisplatin, and Irinotecan in Treating Patients With Metastatic Esophageal Cancer, Gastroesophageal Junction Cancer, or Gastric Cancer That Did Not Respond to Previous Irinotecan and Cisplatin
NCT00397904 ·Status: COMPLETED ·Phase: PHASE2
-
Albumin-bound Paclitaxel-based Second-line Treatment Regimens for Locally Advanced or Metastatic G/GEJ Adenocarcinoma
NCT07389876 ·Status: RECRUITING
-
A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer
NCT03505320 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Neoadjuvant Cadonilimab Combined With Perioperative Oxaliplatin Plus S1 for Diffuse or Mixed Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
NCT06949033 ·Status: RECRUITING ·Phase: PHASE3
-
A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)
NCT03281369 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.
NCT05322577 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer
NCT00006038 ·Status: COMPLETED ·Phase: PHASE2
-
Cisplatin and Irinotecan in Treating Patients With Locally Advanced or Metastatic Esophageal or Gastric Cancer
NCT00003055 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial
NCT06310473 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Chemotherapy and Pembrolizumab, Followed by Pembrolizumab and Olaparib As Firstline Therapy in Her-2 Negative Gastric/GEJ Adenocarcinoma
NCT05268510 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
NCT03653507 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Clinical Study of Sintilimab Combined With Chemothrapy Versus Chemotherapy as Adjuvant Therapy for Gastric/Gastroesophageal Junction Adenocarcinoma
NCT07492615 ·Status: RECRUITING ·Phase: PHASE2
-
Phase II Study of Ramucirumab With Chemotherapy in Patients With Metastatic Gastroesophageal Junction and Gastric Cancer
NCT02726399 ·Status: TERMINATED ·Phase: PHASE2