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Measuring Blood Vessel Density in the Optic Nerve of Multiple Sclerosis Patients With OCTA

NCT07629804 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 54

Last updated 2026-06-05

No results posted yet for this study

Summary

The goal of this observational study is to learn about the effect of multiple sclerosis on the blood flow of the optic nerve of affected patients compared to normal subjects by OCTA. The main question it aims to answer is:

1. Does MS change the blood flow in the optic nerve?
2. If it does, can measuring this blood flow be used as a simple sign (a biomarker) to help doctors understand and manage MS?

We used a quick and painless eye scan called Optical Coherence Tomography Angiography (OCTA). This special scan takes detailed pictures of the blood vessels in the optic nerve without needing any injections. We performed this scan on two groups of people: one group with MS and one group without MS, and then compare the results.

In simple terms, why is this important? If we can show that MS affects the optic nerve blood vessels, it could give us a new, quick way to monitor the disease and see how it is progressing, just by doing a simple eye scan.

Conditions

Interventions

DIAGNOSTIC_TEST

Optical Coherence Tomography Angiography

optic nerve head analysis as regards the vessel density and retinal nerve fiber layer thickness and ganglion cell complex analysis as regards thickness and focal loss volume and global loss volume.

Sponsors & Collaborators

  • Fayoum University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-05
Primary Completion
2025-08-03
Completion
2025-08-03
FDA Device
Yes

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07629804 on ClinicalTrials.gov