MedTrace Logo

Evaluation of the Relationship Between Optic Nerve Diameter and Optic Nerve Sheath Diameter Measured by Transorbital Sonography With Clinical, Radiological, and Electrophysiological Parameters in Multiple Sclerosis Patients

NCT06533930 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 136

Last updated 2025-08-29

No results posted yet for this study

Summary

The primary aim of this study is to evaluate the reliability of optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) measurements made with transorbital sonography (TOS) and magnetic resonance imaging (MRI) in patient groups that may progress with subclinical optic atrophy over time, such as those with multiple sclerosis (MS). The secondary aims of this study are to compare the relationship of TOS with visual evoked potentials (VEP) and optical coherence tomography (OCT) parameters used in the assessment of the afferent visual pathway in MS and its clinical subtypes and to evaluate the potential of TOS as a diagnostic and monitoring tool for detecting optic nerve atrophy, subclinical axonal loss, and clinical disability in MS.

Conditions

Interventions

OTHER

Transorbital Sonography

OND and ONSD of participants in the MS patient group and healthy control group were measured by TOS.

OTHER

Orbita Magnetic Resonance Imaging

OND and ONSD of participants in the MS patient group were measured by orbita MRI.

OTHER

Visual Evoked Potentials

P100 amplitude and P100 latency values of participants in the MS patient group were measured by VEP.

OTHER

Optical Coherence Tomography

pRNFL thickness of participants in the MS patient group were measured by OCT.

Sponsors & Collaborators

  • Kutahya Health Sciences University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2024-04-01
Completion
2024-04-01

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06533930 on ClinicalTrials.gov