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Smart Discharges for Older Children

NCT07629154 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 4000

Last updated 2026-06-15

No results posted yet for this study

Summary

This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are discharged in East Africa.

In low- and middle-income countries, about 5% of children discharged after hospitalization for sepsis will die in the weeks after returning home. Doctors and parents are often unaware of this period of vulnerability and are poorly equipped to identify or handle this critical situation. This project builds on past work that developed and evaluated models and the Smart Discharges program to predict, during hospitalization, an individual child's risk of recurrent illness and mortality, as well as to provide additional post-discharge support to at-risk children.

Participants will be enrolled from facilities once they are admitted, collecting clinical and social variables. They will then be followed until 6 months post-discharge to understand what happens to them after they return home. This data will be evaluated to identify which variables collected at facilities can be predictive of mortality and recurrent illness after discharge.

Conditions

Interventions

OTHER

No Intervention: Observational Cohort

This is a non-interventional study

Sponsors & Collaborators

  • University of California, San Francisco

    collaborator OTHER

  • World Alliance for Lung and Intensive Care Medicine in Uganda

    collaborator UNKNOWN

  • Catholic University of Health and Allied Sciences

    collaborator OTHER

  • Centre Hospitalier Universitaire de Kigali

    collaborator UNKNOWN

  • University of British Columbia

    lead OTHER

Eligibility

Min Age
5 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-02
Primary Completion
2027-04-30
Completion
2027-04-30

Countries

  • United States
  • Canada
  • Rwanda
  • Tanzania
  • Uganda

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07629154 on ClinicalTrials.gov