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Vaginal Fluid Derived Biomarkers in the Early Detection and Evolution of Gynaecological Cancers

NCT07622953 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2026-06-03

No results posted yet for this study

Summary

This study will investigate vaginal secretions in those patients with cancer versus those who are cancer free and compare changes in specific markers that change when a cancer first develops.

Patients who are being investigated for any gynaecological cancer, undergoing surgery to reduce their risk of gynaecological cancer and those with confirmed gynaecological cancer undergoing anti-cancer treatment will be approached to take part in this study.

Participants will be asked to provide an extra blood test, urine sample and high vaginal swab in addition to surplus primary tissue and ascitic fluid that is left over from routine surgical procedures. Specific markers will be compared in patients who have evidence of gynaecological cancer versus those that do not. Changes in these markers during anti-cancer treatment will also be compared to see how these change over time. This could improve the detection and monitoring of gynaecological cancers in those people at highest risk of developing it by using non-invasive multi-cancer early detection tests developed at the University of Southampton.

Conditions

  • Gynaecological Cancers

Sponsors & Collaborators

  • Experimental Cancer Medicine Centres

    collaborator OTHER

  • The Eve Appeal

    collaborator UNKNOWN

  • Southampton Clinical Trials Unit

    collaborator UNKNOWN

  • Daye BioTech

    collaborator UNKNOWN

  • University of Oxford

    collaborator OTHER

  • University Hospital Southampton NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Dr Jemma Longley · University Hospital Southampton NHS Foundation Trust

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-14
Primary Completion
2030-03-02
Completion
2030-07-02

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07622953 on ClinicalTrials.gov