IL-15 Enhanced NK Cell Therapy for Solid Tumors
NCT07621471 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2026-06-02
Summary
A single-arm, Phase 1 study evaluating safety, tolerability, and preliminary efficacy of IL-15 enhanced engineered NK cells in patients with refractory relapsed or metastatic solid tumors.
Conditions
Interventions
- DRUG
-
IL-15 enhanced engineered NK cells
Genetically engineered NK cells expressing IL-15. Administered intravenously. See protocol for dose details.
- BIOLOGICAL
-
IL-15 Enhanced Engineered NK Cells
Genetically engineered NK cells expressing IL-15
Sponsors & Collaborators
-
Genovn Therapeutics (Suzhou) Co., Ltd.
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-07-01
- Primary Completion
- 2028-12-31
- Completion
- 2028-12-31
Countries
- China
Study Locations
More Related Trials
-
NK Cell-based Immunotherapy as Maintenance Therapy for Small-Cell Lung Cancer.
NCT03410368 ·Status: UNKNOWN ·Phase: PHASE2
-
NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT05247957 ·Status: TERMINATED ·Phase: NA
-
NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors
NCT01875601 ·Status: COMPLETED ·Phase: PHASE1
-
A Trial to Evaluate the Safety and Preliminary Efficacy of iNK in the Treatment of Subjects With Solid Tumor
NCT06245018 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Safety and Efficacy of Allogeneic NK Cells Therapy in Patients With Advanced Hepatocellular Carcinoma
NCT04162158 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Safety of SNK01 in Subjects With Pathologically Confirmed Metastatic and/or Unresectable Cancer Refractory to Conventional Therapy
NCT03941262 ·Status: COMPLETED ·Phase: PHASE1
-
PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC
NCT06239220 ·Status: RECRUITING ·Phase: PHASE2
-
NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors
NCT04270461 ·Status: WITHDRAWN ·Phase: PHASE1
-
Clinical Study of a Personalized Neoantigen Cancer Vaccine in Treating Patients With Advanced Malignant Tumor
NCT03662815 ·Status: UNKNOWN ·Phase: PHASE1
-
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
NCT03645928 ·Status: TERMINATED ·Phase: PHASE2
-
Continuous Infusion of rhIL-15 for Adults With Advanced Cancer
NCT01572493 ·Status: COMPLETED ·Phase: PHASE1
-
Comparison of Autogenic and Allogenic NK Immunotherapy on the Outcome of Recurrent Solid Tumors
NCT02853903 ·Status: COMPLETED ·Phase: PHASE2
-
NK Cell Therapy for Malignant Solid Brain Tumors
NCT07552233 ·Status: RECRUITING ·Phase: NA
-
A Trial to Evaluate the Safety and Efficacy of NK Cells in Subjects With Myelodysplastic Syndromes
NCT05371730 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory or Metastatic Solid Tumors
NCT04794972 ·Status: RECRUITING ·Phase: PHASE1
-
Hepatic Artery Transfusion of NKG2D CAR-NK Cells Followed by Intravenous Infusion of NKG2D CAR-T Cells to Treat Patients With Advanced Solid Tumors With Liver Metastases Who Have Failed Standard Treatments: a Phase I Exploratory Clinical Trial
NCT07021534 ·Status: RECRUITING ·Phase: PHASE1
-
NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors
NCT05131763 ·Status: UNKNOWN ·Phase: PHASE1
-
Two-Part, Open-Label, Multi-Center, Phase 1/2 Study of BIW-8962 as Monotherapy in Subjects With Lung Cancer
NCT01898156 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Treatment of Malignant Tumors With NK Cell
NCT05143125 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma
NCT07211737 ·Status: RECRUITING ·Phase: PHASE1
-
Study of Autologous Immune Killer Cells in Patients With Late Stage Hepatocellular Carcinoma or Lung Cancer
NCT03515252 ·Status: COMPLETED ·Phase: PHASE1
-
Universal Dual-target NKG2D-NKp44 CAR-T Cells in Advanced Solid Tumors
NCT05976906 ·Status: UNKNOWN ·Phase: PHASE1
-
Targeted Natural Killer (NK) Cell Based Adoptive Immunotherapy for the Treatment of Patients With Non-Small Cell Lung Cancer (NSCLC) After Radiochemotherapy (RCT)
NCT02118415 ·Status: COMPLETED ·Phase: PHASE2
-
Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer
NCT04847466 ·Status: COMPLETED ·Phase: PHASE2
-
NKG2D CAR-T(KD-025) in the Treatment of Advanced NKG2DL+ Solid Tumors
NCT06509490 ·Status: RECRUITING ·Phase: NA